瞬间焕新：基于亚硝基硫醇、可控超氧化物形成及导致过氧亚硝酸盐的“多米诺”反应的天然三组分抗菌组合。
Flush with a flash: natural three-component antimicrobial combinations based on -nitrosothiols, controlled superoxide formation and "domino" reactions leading to peroxynitrite.
作者信息
Alhasan Rama, Kharma Ammar, Nasim Muhammad Jawad, Abdin Ahmad Yaman, Bonetti Justine, Giummelly Philippe, Ejike Chukwunonso E C C, Leroy Pierre, Gaucher Caroline, Jacob Claus
机构信息
Division of Bioorganic Chemistry , School of Pharmacy , Saarland University , D-66123 Saarbruecken , Germany . Email:
Université de Lorraine , CITHEFOR , F-54000 Nancy , France.
出版信息
Medchemcomm. 2018 Oct 24;9(12):1994-1999. doi: 10.1039/c8md00414e. eCollection 2018 Dec 1.
Abstract
-Nitrosothiols are ˙NO releasing agents renowned for vasodilatory and antioxidant properties. O˙ promotes their decomposition, forming highly aggressive peroxynitrite ions (ONOO). Since the production of O˙ can be controlled by enzymes or by visible light, such otherwise harmless components can be turned into effective antimicrobial and nematicidal combinations with numerous potential applications in medicine.
摘要
亚硝基硫醇是一类以血管舒张和抗氧化特性而闻名的一氧化氮释放剂。超氧阴离子（O˙）会促使它们分解，形成极具攻击性的过氧亚硝酸根离子（ONOO）。由于超氧阴离子的产生可以通过酶或可见光来控制，这些原本无害的成分可以转化为有效的抗菌和杀线虫组合，在医学上有众多潜在应用。
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