S-亚硝基谷胱甘肽
S-nitrosoglutathione.
作者信息
Broniowska Katarzyna A, Diers Anne R, Hogg Neil
机构信息
Department of Biochemistry, Medical College of Wisconsin, WI, USA.
出版信息
Biochim Biophys Acta. 2013 May;1830(5):3173-81. doi: 10.1016/j.bbagen.2013.02.004. Epub 2013 Feb 14.
Abstract
BACKGROUND
S-Nitrosoglutathione (GSNO) is the S-nitrosated derivative of glutathione and is thought to be a critical mediator of the down stream signaling effects of nitric oxide (NO). GSNO has also been implicated as a contributor to various disease states.
SCOPE OF REVIEW
This review focuses on the chemical nature of GSNO, its biological activities, the evidence that it is an endogenous mediator of NO action, and implications for therapeutic use.
MAJOR CONCLUSIONS
GSNO clearly exerts its cellular actions through both NO- and S-nitrosation-dependent mechanisms; however, the chemical and biological aspects of this compound should be placed in the context of S-nitrosation as a whole.
GENERAL SIGNIFICANCE
GSNO is a central intermediate in formation and degradation of cellular S-nitrosothiols with potential therapeutic applications; thus, it remains an important molecule of study. This article is part of a Special Issue entitled Cellular functions of glutathione.
摘要
背景
S-亚硝基谷胱甘肽（GSNO）是谷胱甘肽的S-亚硝化衍生物，被认为是一氧化氮（NO）下游信号效应的关键介质。GSNO也被认为与多种疾病状态有关。
综述范围
本综述聚焦于GSNO的化学性质、生物学活性、其作为NO作用内源性介质的证据以及其治疗应用前景。
主要结论
GSNO显然通过依赖NO和S-亚硝化的机制发挥其细胞作用；然而，该化合物的化学和生物学方面应置于整个S-亚硝化的背景下考虑。
普遍意义
GSNO是细胞内S-亚硝基硫醇形成和降解的核心中间体，具有潜在的治疗应用；因此，它仍然是一个重要的研究分子。本文是名为“谷胱甘肽的细胞功能”的特刊的一部分。
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