Li Yan, He Meizhi, Zou Ziyuan, Bian Xiaohui, Huang Xiaowen, Yang Chen, Wei Shuyi, Dai Shixue
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
PeerJ. 2019 Jan 11;6:e6178. doi: 10.7717/peerj.6178. eCollection 2019.
Researches on artificial livers greatly contribute to the clinical treatments for liver failure. This study aimed to evaluate the research output of artificial livers and citations from 2004 to 2017 through a bibliometric analysis.
A list of included articles on artificial livers were generated after a comprehensive search of the Web of Science Core Collection (from 2004 to 2017) with the following basic information: number of publications, citations, publication year, country of origin, authors and authorship, funding source, journals, institutions, keywords, and research area.
A total of 968 included articles ranged from 47 citations to 394 citations with a fluctuation. The publications were distributed in 12 countries, led by China ( = 212) and the US ( = 207). There were strong correlations of the number of citations with authors ( = 0.133, < 0.001), and countries ( = 0.275, < 0.001), while no correlations of the number of citations with the years since publication ( = 0.016, = 0.216), and funding ( < 0.001, = 0.770) were identified. Keyword analysis demonstrated that with the specific change of "acute liver failure," decrease in "bioartificial livers" and "hepatocyte," and increase in "tissue engineering" were identified. The top 53 cited keyword and keyword plus (including some duplicates counts) were identified, led by bioartificial liver (405 citations) and hepatocyte (248 citations). The top 50 cited keywords bursts were mainly "Blood" (2004-2008), "hepatocyte like cell" (2008-2015), and "tissue engineering" (2014-2017). All keywords could be classified into four categories: bioartificial livers (57.40%), blood purification (25.00%), clinical (14.81%), and other artificial organs (2.78%).
This study shows the process and tendency of artificial liver research with a comprehensive analysis on artificial livers. However, although it seems that the future of artificial livers seems brighter for hepatocyte transplantation, the systems of artificial livers now are inclined on focusing on blood purification, plasma exchange, etc.
人工肝研究对肝衰竭的临床治疗有很大贡献。本研究旨在通过文献计量分析评估2004年至2017年人工肝的研究产出及被引情况。
在科学网核心合集（2004年至2017年）进行全面检索后，生成了一份关于人工肝的纳入文章列表，包含以下基本信息：出版物数量、被引次数、出版年份、原产国、作者及作者身份、资金来源、期刊、机构、关键词和研究领域。
总共968篇纳入文章的被引次数从47次到394次不等，呈波动状态。这些出版物分布在12个国家，以中国（=212篇）和美国（=207篇）为首。被引次数与作者数量（=0.133，<0.001）以及国家数量（=0.275，<0.001）之间存在强相关性，而被引次数与出版年份（=0.016，=0.216）以及资金（<0.001，=0.770）之间未发现相关性。关键词分析表明，随着“急性肝衰竭”的特定变化，“生物人工肝”和“肝细胞”有所减少，而“组织工程”有所增加。确定了被引次数排名前53位的关键词及关键词加（包括一些重复计数），以生物人工肝（405次被引）和肝细胞（248次被引）为首。被引次数排名前50位的关键词爆发主要集中在“血液”（2004 - 2008年）、“肝样细胞”（2008 - 2015年）和“组织工程”（2014 - 2017年）。所有关键词可分为四类：生物人工肝（57.40%）、血液净化（25.00%）、临床（14.81%）和其他人工器官（2.
