1 Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, University College London, London, United Kingdom.
2 UCL Ear Institute, The Royal National Throat Nose and Ear Hospital, London, United Kingdom.
Tissue Eng Part C Methods. 2019 Feb;25(2):93-102. doi: 10.1089/ten.TEC.2018.0241.
This article describes a method for engrafting epithelial progenitor cells to a revascularized scaffold in a protective and supportive collagen-rich environment. This method has the potential to overcome two key limitations of existing grafting techniques as epithelial cells are protected from mechanical shear and the relatively hypoxic phase that occurs while grafts revascularize, offering the opportunity to provide epithelial cells to decellularized allografts at the point of implantation. Advances in this area will improve the safety and efficacy of bioengineered organ transplantation.
本文描述了一种将上皮祖细胞种植到富含胶原蛋白的有血管化支架中的方法，该方法可提供一个保护性和支持性的环境。该方法有可能克服现有移植技术的两个关键限制，因为上皮细胞可以免受机械剪切和移植物再血管化过程中相对缺氧的影响，从而有机会在植入时向去细胞同种异体移植物提供上皮细胞。该领域的进展将提高生物工程器官移植的安全性和有效性。
