Zurawska-Klis Monika, Cypryk Katarzyna
Department of Internal Diseases and Diabetology, Medical University of Lodz, Pomorska Str. 251, 92-213 Lodz, Poland.
Curr Diabetes Rev. 2019;15(6):429-434. doi: 10.2174/1573399815666190115143538.
The potential influence of pregnancy and parity on the risk of chronic diabetic complications is a matter of great concern and constant discussion. This aspect seems relevant and should be the subject of thorough discussion with the woman planning childbirth.
Current data concerning the impact of pregnancy and parity covers primarily retinopathy and nephropathy, while the aspects of neuropathy and macrovascular complications are unsatisfactorily documented. Majority of studies focus on single complication only, while the number of papers assessing this problem in a complex setting is limited. The available body of evidence concerns mainly the short-term impact of pregnancy on diabetic chronic complications while the data concerning the longer perspective are scarce. Moreover, the results found in the available literature are conflicting. The aim of the study was to summarize all available data concerning the longer impact of parity on the chronic complications in the women with type 1 diabetes.
PubMed database has been searched between October 2013 and September 2018 and all relevant papers were selected. This review summarizes data on the impact of pregnancy and parity on chronic complications in type 1 diabetic women.
Current data assessing this matter in a complex way are limited, and the available results are controversial. It seems however that pregnancy itself may rather influence pre-existing diabetic complication than affect risk of its development. Additionally, evidence suggests that any deleterious changes appearing during pregnancy are transient and tend to remit after delivery.
It seems that neither pregnancy nor parity affects the risk of diabetic chronic complications in the longer perspective.
妊娠和生育次数对慢性糖尿病并发症风险的潜在影响是备受关注且不断被讨论的问题。这一方面似乎很重要，应该与计划分娩的女性进行深入讨论。
目前关于妊娠和生育次数影响的数据主要涉及视网膜病变和肾病，而神经病变和大血管并发症方面的记录并不令人满意。大多数研究仅关注单一并发症，而在综合背景下评估该问题的论文数量有限。现有证据主要涉及妊娠对糖尿病慢性并发症的短期影响，而关于更长期影响的数据则很少。此外，现有文献中的结果相互矛盾。本研究的目的是总结所有关于生育次数对1型糖尿病女性慢性并发症长期影响的可用数据。
在2013年10月至2018年9月期间检索了PubMed数据库，并选择了所有相关论文。本综述总结了妊娠和生育次数对1型糖尿病女性慢性并发症影响的数据。
目前以综合方式评估此事的数据有限，现有结果存在争议。然而，妊娠本身似乎更可能影响已有的糖尿病并发症，而不是影响其发生风险。此外，有证据表明，妊娠期间出现的任何有害变化都是短暂的，分娩后往往会缓解。
从长远来看。妊娠和生育次数似乎都不会影响糖尿病慢性并发症的风险。
