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[2018年欧洲动脉高血压管理指南——有哪些变化?]

[European guidelines for the management of arterial hypertension 2018-what has changed?].

作者信息

Jung S, Schmieder R E

机构信息

Medizinische Klinik 4 - Nephrologie und Hypertensiologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen (FAU), Ulmenweg 18, 91054, Erlangen, Deutschland.

出版信息

Internist (Berl). 2019 Feb;60(2):202-208. doi: 10.1007/s00108-018-0552-9.

DOI:10.1007/s00108-018-0552-9
PMID:30649580
Abstract

BACKGROUND

In November 2017, the latest American guidelines for the management of arterial hypertension were published. With these guidelines lowering the threshold for hypertension to 130/80 mm Hg, the latest European guidelines were expected with excitement.

OBJECTIVES

This article gives an overview on the European Society of Cardiology (ESC) and European Society of Hypertension (ESH) 2018 guidelines for the management of arterial hypertension, thereby identifying the most relevant changes in comparison to previous guidelines.

CURRENT DATA

The latest 2018 ESC/ESH guidelines adhere to the previous definition of hypertension, in which a blood pressure of 140/90 mm Hg is considered as threshold for diagnosis. In contrast, there was a change in blood pressure treatment target from below 140/90 to between 120-129/70-79 mm Hg in patients < 65 years if well tolerated. Among patients ≥ 65 years, a systolic blood pressure between 130 and 139 mm Hg is recommended, whereas a diastolic blood pressure between 70 and 79 mm Hg should be targeted. Additionally the guidelines recommend the use of fixed dose combinations as first choice instead of monotherapy to improve adherence. Interventional treatment strategies should only be applied in carefully selected patients at experienced centers and are not recommended outside of clinical studies and registers. Furthermore, the chapters regarding initiation of blood pressure-lowering therapy and clinical evaluation as well as management of hypertension emergencies have been outlined.

CONCLUSIONS

The latest European guidelines for the management of hypertension include several changes. One of the most important aspects is that-in contrast to the American guidelines-the threshold for diagnosis remains at 140/90 mm Hg, whereas treatment target range has been lowered by roughly 10 mm Hg and single pill fixed dose combinations are recommended.

摘要

背景

2017年11月,美国最新的动脉高血压管理指南发布。随着这些指南将高血压阈值降至130/80 mmHg,人们满怀期待地等待最新的欧洲指南。

目的

本文概述了欧洲心脏病学会(ESC)和欧洲高血压学会(ESH)2018年动脉高血压管理指南,从而找出与以往指南相比最相关的变化。

当前数据

2018年最新的ESC/ESH指南沿用了之前的高血压定义,即血压140/90 mmHg被视为诊断阈值。相比之下,对于65岁以下且耐受性良好的患者,血压治疗目标从低于140/90 mmHg变为120 - 129/70 - 79 mmHg。在65岁及以上的患者中,推荐收缩压在130至139 mmHg之间,舒张压应以70至79 mmHg为目标。此外,指南推荐首选使用固定剂量复方制剂而非单药治疗以提高依从性。介入治疗策略仅应在经验丰富的中心对精心挑选的患者应用,不建议在临床研究和登记之外使用。此外,还概述了关于启动降压治疗、临床评估以及高血压急症管理的章节。

结论

最新的欧洲高血压管理指南包含多项变化。其中最重要的一个方面是,与美国指南不同,诊断阈值仍为140/90 mmHg,而治疗目标范围降低了约10 mmHg,并且推荐使用单片固定剂量复方制剂。

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