Baranowski Tom, Motil Kathleen J, Moreno Jennette P
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA.
Curr Nutr Rep. 2019 Jan 16. doi: 10.1007/s13668-019-0256-3.
The simple energy balance model of obesity is inconsistent with the available findings on obesity etiology, prevention, and treatment. Yet, the most commonly stated causes of pediatric obesity are predicated on this model. A more comprehensive biological model is needed upon which to base behavioral interventions aimed at obesity prevention. In this light, alternative etiologies are little investigated and thereby poorly understood.
Three candidate alternate etiologies are briefly presented: infectobesity, the gut microbiome, and circadian rhythms. Behavioral child obesity preventive investigators need to collaborate with biological colleagues to more intensively analyze the behavioral aspects of these etiologies and to generate innovative procedures for preventing a multi-etiological problem, e.g., group risk analysis, triaging for likely causes of obesity.
肥胖的简单能量平衡模型与肥胖病因、预防和治疗的现有研究结果不一致。然而，小儿肥胖最常提及的病因正是基于此模型。需要一个更全面的生物学模型，以此为基础开展旨在预防肥胖的行为干预。鉴于此，替代病因很少被研究，因此了解不足。
简要介绍了三种候选替代病因：感染致肥胖、肠道微生物群和昼夜节律。预防儿童肥胖的行为学研究人员需要与生物学领域的同行合作，更深入地分析这些病因的行为学方面，并制定创新方法来预防这一多病因问题，例如群体风险分析、对可能的肥胖原因进行分类。
