Sobstyl Michał, Pasterski Tomasz, Brzuszkiewicz-Kuźmicka Grażyna, Aleksandrowicz Marta, Zaczyński Artur
Neurosurgical Department of Postgraduate Medical Center, Warsaw, Poland.
Turk Neurosurg. 2019;29(2):194-204. doi: 10.5137/1019-5149.JTN.21607-17.3.
To assess the health-related quality of life (HRQoL) with the Parkinson"s Disease Questionnaire 39 (PDQ-39) after unilateral subthalamic deep brain stimulation (STN DBS) and to identify correlations between the changes in UPDRS (Unified Parkinson"s Disease Rating Scale) scores and separate PDQ-39 QoL dimensions and PDQ summary index (SI) score at short-term follow-up (FU1) and long-term follow-up (FU2).
We evaluated 33 patients with PD after unilateral STN DBS. All patients were assessed at baseline and at FU1 and at FU2. HRQoL levels were determined by applying PDQ-39 and PD progression was evaluated by parts I-IV of the UPDRS.
All dimensions of PDQ-39 as well as PDQ-39 SI score were highly significantly improved at FU1. The same improvements were mostly visible at FU2 except for psychosocial functioning. The PDQ-39 SI score was reduced by 40 % (p < 0.01) at FU1 and by 25 % (p < 0.01) at FU2. A significant reduction between the UPDRS baseline scores and the UPDRS follow-up scores was noticed for medication off and on conditions under unilateral STN DBS. Interestingly, we did not find strong positive correlations between the improvements of the UPDRS scores and individual PDQ-39 dimensions as well as PDQ-39 SI score.
Improvements in PDQ-39 dimensions and PDQ-39 SI score are maintained at FU1 and except for the aspects of psychosocial functioning at FU2. Different correlations between the improvements of separate UPDRS scores on PDQ-39 dimensions require future studies in larger study groups.
使用帕金森病问卷39项版本（PDQ - 39）评估单侧丘脑底核脑深部电刺激（STN DBS）术后与健康相关的生活质量（HRQoL），并确定在短期随访（FU1）和长期随访（FU2）时，统一帕金森病评定量表（UPDRS）评分变化与PDQ - 39生活质量各维度及PDQ总结指数（SI）评分之间的相关性。
我们评估了33例接受单侧STN DBS的帕金森病患者。所有患者在基线、FU1和FU2时均接受评估。通过应用PDQ - 39确定HRQoL水平，并通过UPDRS的第一至第四部分评估PD进展情况。
在FU1时，PDQ - 39的所有维度以及PDQ - 39 SI评分均有高度显著改善。除心理社会功能外，在FU2时大多可见同样的改善。PDQ - 39 SI评分在FU1时降低了40%（p < 0.01），在FU2时降低了25%（p < 0.01）。在单侧STN DBS的关药和开药状态下，UPDRS基线评分与UPDRS随访评分之间有显著降低。有趣的是，我们未发现UPDRS评分改善与个体PDQ - 39维度以及PDQ - 39 SI评分之间有强正相关。
在FU1时，PDQ - 39维度及PDQ - 39 SI评分得到改善，且在FU2时除心理社会功能方面外仍保持改善。UPDRS各评分改善与PDQ - 39维度之间不同的相关性需要在更大的研究组中进行进一步研究。
