Allsop P, Taylor M B, Grounds R M, Morgan M
Department of Anaesthetics, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
Eur J Anaesthesiol. 1988 Sep;5(5):293-303.
The ventilatory effects of a propofol infusion were studied in 10 females premedicated with atropine and nine with papaveretum and atropine. The infusion, at a rate of 20 mg kg-1 h-1 for 5 min, reducing to 12 mg kg-1 h-1 for 10 min and then 6 mg kg-1 h-1 thereafter, was known to produce a steady-state plasma propofol concentration for 20-25 min after 25 min from commencement. Minute ventilation, tidal volume, frequency and response to breathing carbon dioxide were measured before the infusion and during the steady-state period. Propofol decreased minute ventilation to 56% and 46% (P less than 0.01) of their mean control values in the atropine and papaveretum groups, respectively. Mean tidal volume was decreased to 41-44% (P less than 0.02) by propofol, but a tachypnoea observed in the atropine group during the infusion was absent in the papaveretum group. Propofol alone had no effect on the slopes of the carbon dioxide response curves but did produce a shift to the right (P less than 0.05). Following papaveretum premedication the minute ventilation-carbon dioxide response curve slope, was decreased to 55% of its mean control volume value by the infusion, but this failed to reach statistical significance.
对10名预先使用阿托品的女性和9名预先使用罂粟碱及阿托品的女性，研究了丙泊酚输注的通气效应。已知以20mg·kg⁻¹·h⁻¹的速率输注5分钟，然后减至12mg·kg⁻¹·h⁻¹持续10分钟，此后为6mg·kg⁻¹·h⁻¹，在开始输注25分钟后可产生20 - 25分钟的稳态血浆丙泊酚浓度。在输注前和稳态期测量分钟通气量、潮气量、频率及对二氧化碳呼吸的反应。丙泊酚分别将阿托品组和罂粟碱组的分钟通气量降至其平均对照值的56%和46%（P<0.01）。丙泊酚使平均潮气量降低至41 - 44%（P<0.02），但罂粟碱组在输注期间未观察到阿托品组出现的呼吸急促。单独丙泊酚对二氧化碳反应曲线的斜率无影响，但确实使曲线右移（P<0.05）。预先使用罂粟碱后，输注使分钟通气量 - 二氧化碳反应曲线斜率降至其平均对照值的55%，但未达到统计学显著性。
