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Selective targeting of myeloid-derived suppressor cells in cancer patients through AFP-binding receptors.

作者信息

Pak Vladimir N

机构信息

Freelance Researcher, Toronto, M2R 3T1, Canada.

出版信息

Future Sci OA. 2018 Jun 28;5(1):FSO321. doi: 10.4155/fsoa-2018-0029. eCollection 2019 Jan.

DOI:10.4155/fsoa-2018-0029
PMID:30652015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6331696/
Abstract
摘要

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Selective targeting of myeloid-derived suppressor cells in cancer patients through AFP-binding receptors.通过甲胎蛋白结合受体对癌症患者髓源性抑制细胞进行选择性靶向。
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2
The use of alpha-fetoprotein for the treatment of autoimmune diseases and cancer.甲胎蛋白在自身免疫性疾病和癌症治疗中的应用。
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3
Targeting Alpha-Fetoprotein (AFP)-MHC Complex with CAR T-Cell Therapy for Liver Cancer.用嵌合抗原受体 T 细胞疗法靶向甲胎蛋白（AFP）-MHC 复合物治疗肝癌。
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α-fetoprotein-binding toxins and teratogens against cancer.针对癌症的甲胎蛋白结合毒素和致畸剂。
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Prevention of N-methyl-N-nitrosourea-induced breast cancer by alpha-fetoprotein (AFP)-derived peptide, a peptide derived from the active site of AFP.甲胎蛋白（AFP）衍生肽（一种源自AFP活性位点的肽）对N-甲基-N-亚硝基脲诱导的乳腺癌的预防作用
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The receptor binding fragment of alpha-fetoprotein is a promising new vector for the selective delivery of antineoplastic agents.甲胎蛋白的受体结合片段是一种很有前途的新型载体，可用于选择性递送抗肿瘤药物。
J Drug Target. 2013 May;21(5):458-65. doi: 10.3109/1061186X.2013.765441. Epub 2013 Apr 19.
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Specific cytoplasmic alpha-fetoprotein binding protein in MCF-7 human breast cancer cells and primary breast cancer tissue.MCF-7人乳腺癌细胞和原发性乳腺癌组织中的特异性细胞质甲胎蛋白结合蛋白
Breast Cancer Res Treat. 1987 Dec;10(3):279-86. doi: 10.1007/BF01805765.
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Review of the Third Domain Receptor Binding Fragment of Alphafetoprotein (AFP): Plausible Binding of AFP to Lysophospholipid Receptor Targets.甲胎蛋白（AFP）第三结构域受体结合片段的综述：AFP与溶血磷脂受体靶点的可能结合
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Identification of alpha-fetoprotein-derived peptides recognized by cytotoxic T lymphocytes in HLA-A24+ patients with hepatocellular carcinoma.在HLA - A24 + 肝细胞癌患者中识别细胞毒性T淋巴细胞识别的甲胎蛋白衍生肽。
Int J Cancer. 2006 Mar 1;118(5):1194-204. doi: 10.1002/ijc.21468.
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Elevated serum alpha-fetoprotein level of nude mice bearing hepatoma cells by treatment with monoclonal antibodies to alpha-fetoprotein.通过用抗甲胎蛋白单克隆抗体治疗，荷肝癌细胞裸鼠的血清甲胎蛋白水平升高。
Biochim Biophys Acta. 1993 Sep 8;1182(2):128-32. doi: 10.1016/0925-4439(93)90132-k.

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The Role of Alpha-Fetoprotein (AFP) in Contemporary Oncology: The Path from a Diagnostic Biomarker to an Anticancer Drug.甲胎蛋白（AFP）在当代肿瘤学中的作用：从诊断生物标志物到抗癌药物。
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First report of the unique expression of RECAF (receptor for alfa feto-protein) in adult B-NHL/CLL patients.成人B细胞非霍奇金淋巴瘤/慢性淋巴细胞白血病患者中甲胎蛋白受体（RECAF）独特表达的首次报道。
Blood Res. 2020 Dec 31;55(4):253-261. doi: 10.5045/br.2020.2020070.

本文引用的文献

1
Targeting Myeloid-Derived Suppressor Cells to Bypass Tumor-Induced Immunosuppression.靶向髓系来源抑制细胞以绕过肿瘤诱导的免疫抑制。
Front Immunol. 2018 Mar 2;9:398. doi: 10.3389/fimmu.2018.00398. eCollection 2018.
2
The use of alpha-fetoprotein for the treatment of autoimmune diseases and cancer.甲胎蛋白在自身免疫性疾病和癌症治疗中的应用。
Ther Deliv. 2018 Jan;9(1):37-46. doi: 10.4155/tde-2017-0073.
3
Daunorubicin conjugated with alpha-fetoprotein selectively eliminates myeloid-derived suppressor cells (MDSCs) and inhibits experimental tumor growth.阿霉素与甲胎蛋白偶联可选择性消除髓源性抑制细胞（MDSCs）并抑制实验性肿瘤生长。
Cancer Immunol Immunother. 2018 Jan;67(1):101-111. doi: 10.1007/s00262-017-2067-y. Epub 2017 Sep 27.
4
Myeloid-Derived Suppressor Cells.髓系来源的抑制细胞
Cancer Immunol Res. 2017 Jan;5(1):3-8. doi: 10.1158/2326-6066.CIR-16-0297.
5
Frontline Science: Myeloid-derived suppressor cells (MDSCs) facilitate maternal-fetal tolerance in mice.前沿科学：髓系来源的抑制细胞（MDSCs）促进小鼠的母胎耐受。
J Leukoc Biol. 2017 May;101(5):1091-1101. doi: 10.1189/jlb.1HI1016-306RR. Epub 2016 Dec 22.
6
Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody.使用激动性TRAIL-R2抗体DS-8273a对癌症患者骨髓来源的抑制细胞进行选择性靶向治疗。
Clin Cancer Res. 2017 Jun 15;23(12):2942-2950. doi: 10.1158/1078-0432.CCR-16-1784. Epub 2016 Dec 13.
7
Recombinant human alpha fetoprotein synergistically potentiates the anti-cancer effects of 1'-S-1'-acetoxychavicol acetate when used as a complex against human tumours harbouring AFP-receptors.重组人甲胎蛋白与1'-S-1'-乙酰氧基胡椒酚乙酸酯形成复合物用于对抗带有甲胎蛋白受体的人类肿瘤时，能协同增强其抗癌效果。
Oncotarget. 2015 Jun 30;6(18):16151-67. doi: 10.18632/oncotarget.3951.
8
The use of α-fetoprotein for the delivery of cytotoxic payloads to cancer cells.使用甲胎蛋白将细胞毒性有效载荷递送至癌细胞。
Ther Deliv. 2014 Aug;5(8):885-92. doi: 10.4155/tde.14.59.
9
Alpha-fetoprotein contributes to THP-1 cell invasion and chemotaxis via protein kinase and Gi-protein-dependent pathways.甲胎蛋白通过蛋白激酶和 Gi 蛋白依赖途径促进 THP-1 细胞侵袭和趋化作用。
Mol Cell Biochem. 2013 Jul;379(1-2):283-93. doi: 10.1007/s11010-013-1650-6. Epub 2013 Apr 25.
10
Regulation of Anti-Tumor Activity Using Monoclonal Antibodies to Alpha-Fetoprotein Receptor and after Immunization with This Protein.使用抗甲胎蛋白受体单克隆抗体及用该蛋白免疫后对肿瘤活性的调节
Russ J Immunol. 2001 Oct;6(3):249-256.