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结直肠支架置入术在恶性大肠梗阻中的桥接作用:肿瘤学结局。

Colonic stenting as a bridge to surgery in malignant large bowel obstruction: oncological outcomes.

机构信息

Department of Colorectal Surgery, St James Hospital, Dublin 8, Ireland.

出版信息

Int J Colorectal Dis. 2019 Apr;34(4):613-619. doi: 10.1007/s00384-019-03239-9. Epub 2019 Jan 16.

DOI:10.1007/s00384-019-03239-9
PMID:30652215
Abstract

INTRODUCTION

Stenting of obstructing colorectal cancers obviates the need for emergency surgery, reducing initial morbidity and mortality rate associated with emergency surgery and facilitates full staging of the neoplastic process with an opportunity to optimize the patient for surgery. Some recent publications have suggested however that this approach may be associated with higher local recurrence rates. We examined our outcomes following colonic stenting as a bridge to resection.

METHODS

A database was reviewed (2006-2018) of patients presenting with acute colorectal obstruction that proceeded to endoscopic stenting. We assessed the bridge to surgery strategy, its success, complication rate, and impact on recurrence and survival.

RESULTS

Of a total of 103 patients who presented with acute malignant large bowel obstruction over this time period, 26 patients had potentially curable disease at presentation and underwent stenting as a bridge to surgery. The technical success rate for stenting in those managed as a bridge to surgery was 92% (n = 24/26) with 7.69% (n = 2/26) having a complication. There was one stent-related perforation. Median follow-up of this cohort was 31 months, with a 5-year overall survival of 53.5%.

CONCLUSION

Colorectal stenting as a bridge to resection is a successful management strategy for those presenting with obstructing colorectal obstruction. Selective use is associated with lower rates of stoma formation, greater rates of laparoscopic resections with low complication rates, and acceptable oncological outcomes.

摘要

介绍

阻塞性结直肠癌支架置入术可避免紧急手术的需要,降低与紧急手术相关的初始发病率和死亡率,并为肿瘤过程的全面分期提供便利,有机会优化患者的手术条件。然而,一些最新的出版物表明,这种方法可能与更高的局部复发率相关。我们检查了我们在结直肠支架置入术作为切除桥接方面的结果。

方法

回顾了(2006-2018 年)患有急性结直肠梗阻并进行内镜下支架置入术的患者的数据库。我们评估了手术桥接策略、其成功率、并发症发生率以及对复发和生存的影响。

结果

在这段时间内,共有 103 名患有急性恶性大肠梗阻的患者,其中 26 名患者在就诊时患有潜在可治愈的疾病,并进行了支架置入术作为手术桥接。在作为手术桥接管理的患者中,支架置入的技术成功率为 92%(n=24/26),并发症发生率为 7.69%(n=2/26)。有 1 例支架相关穿孔。该队列的中位随访时间为 31 个月,5 年总生存率为 53.5%。

结论

结直肠支架置入术作为切除桥接是治疗阻塞性结直肠癌梗阻的一种成功的管理策略。选择性使用与造口形成率较低、腹腔镜切除术率较高、并发症发生率较低以及可接受的肿瘤学结果相关。

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2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation.2017 WSES 指南:结直肠肿瘤急症处理——梗阻和穿孔。
World J Emerg Surg. 2018 Aug 13;13:36. doi: 10.1186/s13017-018-0192-3. eCollection 2018.
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Clinical outcomes and factors related to colonic perforations in patients receiving self-expandable metal stent insertion for malignant colorectal obstruction.接受自膨式金属支架置入治疗恶性结直肠梗阻患者的临床结局及与结肠穿孔相关的因素。
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Surgical Outcomes and Risk Factors in Patients Who Underwent Emergency Colorectal Surgery.
低位直肠恶性梗阻支架置入相关挑战:一例报告
J Surg Case Rep. 2024 Sep 10;2024(9):rjad593. doi: 10.1093/jscr/rjad593. eCollection 2024 Sep.
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Colonic stenting: is the bridge to surgery worth its cost? A cost-effectiveness analysis at a single Asian institution.结肠支架置入术:通向手术的桥梁是否物有所值?一家亚洲机构的成本效益分析
Ann Coloproctol. 2024 Dec;40(6):555-563. doi: 10.3393/ac.2023.00738.0105. Epub 2024 Aug 5.
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Management of obstructed colorectal carcinoma in an emergency setting: An update.急诊情况下梗阻性结直肠癌的管理:最新进展
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