碘介导的芳基二炔与羟基的1,5-环化反应：一种合成3-酰基-1-茚酮衍生物的方法。
IO-Mediated 1,5-Cyclization of Aryldiynes with HO: A Way To Access 3-Acyl-1-indenone Derivatives.
作者信息
Zhou Bingwei, Yang Huan, Jin Hongwei, Liu Yunkui
机构信息
State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering , Zhejiang University of Technology , Hangzhou 310014 , People's Republic of China.
出版信息
J Org Chem. 2019 Feb 15;84(4):2169-2177. doi: 10.1021/acs.joc.8b03151. Epub 2019 Jan 28.
A facile IO-mediated 1,5-cyclization of aryldiynes with HO has been successfully developed, leading to a broad range of substituted 3-acyl-1-indenones in moderate to excellent yields. The protocol has advantages of a metal-free process, mild reaction conditions, simple operation, and broad functional group tolerance. In the reaction, HO is used as both a cosolvent and an oxygen source.
已成功开发出一种由碘介导的芳基二炔与HO的简便1,5-环化反应，可中等至优异产率地生成多种取代的3-酰基-1-茚酮。该方法具有无金属过程、反应条件温和、操作简单以及官能团耐受性广等优点。在该反应中，HO既用作助溶剂又用作氧源。
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