阳离子金催化取代的1,5-二炔分子内环化反应合成茚酮衍生物
Cationic Gold-Catalyzed Intramolecular Cyclization of Substituted 1,5-Diynes to Access Indenone Derivatives.
作者信息
Karunakar Galla V, Raju Chittala Emmaniel, Sreenivasulu Gottam, Kumar Perla Bharath, Kadiyala Veerabhushanam, Sridhar Balasubramanian
机构信息
Fluoro and Agrochemicals Department, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500007, India.
Academy of Scientific and Innovative Research, Ghaziabad, 201002, India.
出版信息
Chem Asian J. 2022 Apr 14;17(8):e202101408. doi: 10.1002/asia.202101408. Epub 2022 Mar 19.
An efficient intramolecular cyclization reaction was developed to achieve indenone derivatives. The substituted 1,5-diyenes were converted to the corresponding indenones via a gold-catalyzed organic transformation, and moderate to excellent yields of the title molecules were obtained via formation of two C=O and one C-C bonds under mild reaction conditions in one pot.
开发了一种高效的分子内环化反应以制备茚满二酮衍生物。通过金催化的有机转化，将取代的1,5-二烯转化为相应的茚满二酮，并且在温和的反应条件下通过一锅法形成两个C=O键和一个C-C键，以中等至优异的产率得到目标分子。
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