Wolf B C, Neiman R S
Boston University School of Medicine, Massachusetts.
Hematol Oncol Clin North Am. 1988 Dec;2(4):669-94.
The myeloproliferative and dysmyelopoietic syndromes are complex disorders that are interrelated and not always easily diagnosed on morphologic grounds alone. In particular, in the case of the myeloproliferative diseases, the diagnostic pathologist should avoid the pitfall of attempting to make a definite diagnosis in the absence of appropriate laboratory and clinical data. The morphologic features in given myeloproliferative diseases are not always specific; and, as the disorders evolve, they may closely mimic one another. With respect to the dysmyelopoietic syndromes, care must be taken not to confuse them with megaloblastic anemias or other conditions that do not have the same ominous prognosis. Distinction between the varying syndromes may frequently also be difficult, and on occasion one may have difficulty placing them within the appropriate context. Only careful correlation with clinical laboratory findings and history will result in accurate diagnoses.
骨髓增殖性疾病和骨髓发育异常综合征是复杂的疾病，它们相互关联，仅靠形态学依据并不总是容易诊断。特别是在骨髓增殖性疾病的情况下，诊断病理学家应避免在缺乏适当的实验室和临床数据时试图做出明确诊断的陷阱。特定骨髓增殖性疾病的形态学特征并不总是具有特异性；而且，随着疾病的发展，它们可能彼此极为相似。关于骨髓发育异常综合征，必须注意不要将它们与巨幼细胞贫血或其他预后不那么凶险的疾病相混淆。区分不同的综合征通常也很困难，有时可能难以将它们置于适当的背景中。只有仔细结合临床实验室检查结果和病史才能得出准确的诊断。
