Department of Dermatology and Allergy Centre, Odense University Hospital, DK-5000 Odense, Denmark.
Acta Derm Venereol. 2019 Apr 1;99(4):360-369. doi: 10.2340/00015555-3123.
Skin cancer has become the most common type of cancer worldwide as a result of environmental exposure and medical treatments. A small group of patients are genetically predisposed to skin cancer and this article is intended as a diagnostic tool when encountering patients with multiple skin cancer lesions. The disorders are described with clinical characteristics, genetics and management. The most common syndromes associated with basal cell carcinoma are: Gorlin-Goltz syndrome, Rombo syndrome, and Bazex-Dupré-Christol syndrome. Multiple squamous cell carcinomas can be related to: xeroderma pigmentosum, Ferguson-Smith, Muir-Torre syndrome, Mibelli-type porokeratosis, keratitis-ichthyosis-deafness syndrome, Rothmund-Thomson syndrome, Bloom syndrome, and epidermodysplasia verruciformis. Malignant melanoma can be inherited, as in familial atypical multiple mole melanoma syndrome.
由于环境暴露和医疗治疗，皮肤癌已成为全球最常见的癌症类型。一小部分患者具有皮肤癌的遗传易感性，本文旨在作为遇到多发性皮肤癌病变患者时的诊断工具。这些疾病的描述包括临床特征、遗传学和管理。与基底细胞癌相关的最常见综合征有：Gorlin-Goltz 综合征、Rombo 综合征和 Bazex-Dupré-Christol 综合征。多发性鳞状细胞癌可能与以下疾病有关：着色性干皮病、Ferguson-Smith 综合征、Muir-Torre 综合征、Mibelli 型汗孔角化病、角膜炎-鱼鳞癣-耳聋综合征、Rothmund-Thomson 综合征、Bloom 综合征和疣状表皮发育不良。恶性黑色素瘤可能是遗传性的，如家族性非典型多发性黑素瘤综合征。
