Burkhardt R
Abteilung für Knochenmarksdiagnostik an der Medizinischen Klinik Innenstadt, Universität München.
Hematol Oncol Clin North Am. 1988 Dec;2(4):695-733.
Megakaryocytic disorders induce serious consequences: myelofibrosis and osteomyelosclerosis, hemorrhage, and thrombosis. They are characterized by four main structural types: myeloproliferation, dysmegakaryocytosis, amegakaryocytosis, and secondary megakaryocytosis. Whereas the first and third are primarily defined by histology, the second and fourth are to be interpreted only in the context of clinical findings. Nevertheless, bone marrow biopsy has revealed marked quantitative and qualitative anomalies of megakaryocytes also in these groups: isolation, pleomorphism, and degeneration of nuclei, and immaturity, vacuolization, and disruption of cytoplasm. The pathophysiologic impact of these impressive changes is almost unknown. It deserves further consideration.
骨髓纤维化和骨质硬化、出血以及血栓形成。它们具有四种主要结构类型：骨髓增殖、巨核细胞生成异常、无巨核细胞症以及继发性巨核细胞增多症。虽然第一种和第三种主要通过组织学定义，但第二种和第四种仅在临床发现的背景下才能得到解释。然而，骨髓活检也揭示了这些组中巨核细胞存在明显的数量和质量异常：细胞核的分离、多形性和变性，以及细胞质的不成熟、空泡化和破坏。这些显著变化的病理生理影响几乎未知，值得进一步研究。
