From the Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, OH.
Circ Res. 2019 Jan 18;124(2):202-204. doi: 10.1161/CIRCRESAHA.118.314362.
A half century of research and more than 75,000 publications have cemented the foundational role of integrins as major conduits of communication between the extracellular environment and the interior of cells. By serving as cell-surface receptors for numerous extracellular ligands, integrin α and β heterodimers are integrally involved in the physiological and pathophysiological responses of virtually all cell types. Excessive or suppressed ligand binding to integrins are implicated in many diseases, including cancer, inflammation and cardiovascular diseases.
半个世纪的研究和超过 75000 篇出版物巩固了整合素作为细胞外环境与细胞内部之间主要通讯渠道的基础作用。整合素 α 和 β 异二聚体作为许多细胞外配体的细胞表面受体，整体上参与了几乎所有细胞类型的生理和病理生理反应。整合素与配体的过度或抑制结合与许多疾病有关，包括癌症、炎症和心血管疾病。
