Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, Beijing, China.
J Magn Reson Imaging. 2019 Aug;50(2):541-551. doi: 10.1002/jmri.26576. Epub 2019 Jan 17.
The reward-related regions have been considered a crucial component in the regulation of eating behavior. Furthermore, appetite-related regions associated with reward can influence eating behaviors through altered functional activity related to food in brain areas associated with emotion, memory, sensory processing, motor function, and cognitive control.
To investigate the key nodes in obese females of reward-related regions and, based on key nodes, to evaluate the directionality of functional connectivity between key nodes and appetite-related regions.
Prospective.
Twenty-eight obese and 28 normal-weight female controls of similar age.
FIELD STRENGTH/SEQUENCE: 3.0 T MRI and echo planar imaging (EPI) sequence, 3D BRAVO sequence.
The fMRI data preprocessing was based on the Data Processing & Analysis of Brain Imaging and Statistical Parametric Mapping 12. Degree centrality calculation was based on the GRETNA toolkit and granger causality analysis were based on the DynamicBC toolbox. Statistical Tests: Independent two-sample t-tests were used to assess the differences in demographic and clinical data between two groups. Two-sample t-tests were conducted to test the difference in degree centrality and effective connectivity of key nodes between two groups.
Compared with normal-weight controls, obese females showed an increased degree centrality in the left ventral striatum/caudate (t = 2.96808, P < 0.05) and decreased degree centrality in right orbitofrontal cortex (OFC) (t = -3.3558, P < 0.05). The obese females showed directional effective connectivity between left ventral striatum/caudate and several regions (left inferior temporal gyrus, fusiform gyrus, postcentral gyrus, and right precentral gyrus) (P < 0.05). Directional effective connectivity was also observed between the right OFC and several regions (left middle temporal gyrus, cuneus, OFC, superior temporal gyrus, middle frontal gyrus, and right inferior parietal lobule) (P < 0.05).
The left ventral striatum/caudate and right OFC are key nodes in reward-related regions. The key nodes with reward processing mainly enhance visual processing of information and further participate in cognitive, attention, and sensorimotor processing.
奖励相关区域被认为是调节进食行为的关键组成部分。此外，与食欲相关的奖励相关区域可以通过改变与食物相关的大脑区域的功能活动来影响进食行为，这些大脑区域与情绪、记忆、感觉处理、运动功能和认知控制有关。
探讨肥胖女性奖励相关区域的关键节点，并基于关键节点，评估关键节点与食欲相关区域之间功能连接的方向性。
前瞻性。
28 名肥胖女性和 28 名年龄相似的正常体重女性对照。
场强/序列：3.0T MRI 和 echo 平面成像（EPI）序列、3D BRAVO 序列。
fMRI 数据预处理基于数据处理与脑成像统计参数映射 12。度中心度计算基于 GRETNA 工具包，格兰杰因果分析基于 DynamicBC 工具包。统计检验：独立两样本 t 检验用于评估两组间人口统计学和临床数据的差异。进行两样本 t 检验以检验两组间关键节点的度中心度和有效连接的差异。
与正常体重对照组相比，肥胖女性的左侧腹侧纹状体/尾状核的度中心度增加（t=2.96808，P<0.05），右侧眶额皮层（OFC）的度中心度降低（t=-3.3558，P<0.05）。肥胖女性的左侧腹侧纹状体/尾状核与几个区域之间存在方向性有效连接（左侧颞下回、梭状回、中央后回和右侧中央前回）（P<0.05）。右侧 OFC 与几个区域（左侧颞中回、楔前叶、OFC、颞上回、中额回和右侧下顶叶）之间也存在方向性有效连接（P<0.05）。
左侧腹侧纹状体/尾状核和右侧 OFC 是奖励相关区域的关键节点。具有奖励处理功能的关键节点主要增强信息的视觉处理，并进一步参与认知、注意力和感觉运动处理。
