Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, Beijing, 100050, China.
Appetite. 2021 Apr 1;159:105055. doi: 10.1016/j.appet.2020.105055. Epub 2020 Nov 25.
Abnormal activities in reward-related regions are associated with overeating or obesity. Preliminary studies have shown that changes in neural activity in obesity include not only regional reward regions abnormalities but also impairments in the communication between reward-related regions and multiple functional areas. A recent study has shown that the transitions between different neural networks are nonrandom and hierarchical, and that activation of particular brain networks is more likely to occur after other brain networks. The aims of this study were to investigate the key nodes of reward-related regions in obese males and explore the hierarchical integrated processing of key nodes. Twenty-four obese males and 24 normal-weight male controls of similar ages were recruited. The fMRI data were acquired using 3.0 T MRI. The fMRI data preprocessing was performed in DPABI and SPM 12. Degree centrality analyses were conducted using GRETNA toolkit, and Granger causality analyses were calculated using DynamicBC toolbox. Decreased degree centrality was observed in left ventral medial prefrontal cortex (vmPFC) and right parahippocampal/hippocampal gyrus in group with obesity. The group with obesity demonstrated increased effective connectivity between left vmPFC and several regions (left inferior temporal gyrus, left supplementary motor area, right insular cortex, right postcentral gyrus, right paracentral lobule and bilateral fusiform gyrus). Increased effective connectivity was observed between right parahippocampal/hippocampal gyrus and left precentral/postcentral gyrus. Decreased effective connectivity was found between right parahippocampal/hippocampal gyrus and left inferior parietal lobule. This study identified the features of hierarchical interactions between the key reward nodes and multiple function networks. These findings may provide more evidence for the existing view of hierarchical organization in reward processing.
奖励相关区域的异常活动与暴饮暴食或肥胖有关。初步研究表明，肥胖症患者的神经活动变化不仅包括区域奖励区域异常，还包括奖励相关区域与多个功能区域之间的通讯障碍。最近的一项研究表明，不同神经网络之间的转变不是随机的，而是分层的，特定脑网络的激活更有可能在其他脑网络之后发生。本研究旨在探讨肥胖男性奖励相关区域的关键节点，并探索关键节点的分层综合处理。招募了 24 名肥胖男性和 24 名年龄相似的正常体重男性对照者。使用 3.0T MRI 采集 fMRI 数据。使用 DPABI 和 SPM 12 进行 fMRI 数据预处理。使用 GRETNA 工具包进行度中心性分析，使用 DynamicBC 工具包计算 Granger 因果关系分析。肥胖组的左侧腹内侧前额叶皮层(vmPFC)和右侧海马旁回/海马回的度中心性降低。肥胖组左侧 vmPFC 与几个区域（左侧颞下回、左侧辅助运动区、右侧岛叶、右侧中央后回、右侧旁中央小叶和双侧梭状回）之间的有效连接增加。右侧海马旁回/海马回与左侧中央前回/中央后回之间的有效连接增加。右侧海马旁回/海马回与左侧顶下小叶之间的有效连接减少。本研究确定了关键奖励节点与多个功能网络之间分层相互作用的特征。这些发现可能为奖励处理的分层组织现有观点提供更多证据。
