Rensselaer Polytechnic Institute, Materials Science and Engineering, 110 8th St., Troy, NY, 12180, USA.
Freiburg Center for Interactive Materials and Bioinspired Technologies (FIT) and Department of Microsystems Engineering (IMTEK), Albert-Ludwigs-Universität, Georges-Köhler-Allee 105, 79110, Freiburg, Germany.
Angew Chem Int Ed Engl. 2019 Mar 18;58(12):3690-3693. doi: 10.1002/anie.201813810. Epub 2005 Feb 14.
The purpose of this Viewpoint is to discuss the molecular design principles that guide development of synthetic antimicrobial polymers, especially those intended to mimic the structure of host defense peptides (HDPs). In particular, we focus on the principle of "amphiphilic balance" as it relates to some recently developed polyphosphoniums with somewhat atypical structure. We find that the fundamental concept of amphiphilic balance is still applicable to these new polymers, but that the method to achieve such balance is somewhat unique. We then briefly outline the future challenges and opportunities in this field.
本文观点旨在探讨指导合成抗菌聚合物发展的分子设计原则，特别是那些旨在模拟宿主防御肽（HDPs）结构的聚合物。特别是，我们重点关注“两亲平衡”原则，因为它与最近开发的一些结构有些非典型的聚膦有关。我们发现，两亲平衡的基本概念仍然适用于这些新型聚合物，但实现这种平衡的方法有些独特。然后，我们简要概述了该领域未来的挑战和机遇。
