CAS Key Lab of Colloid, Interface and Chemical Thermodynamics , Institute of Chemistry, Chinese Academy of Sciences , No. 2, First North Street , Zhongguancun, Beijing 100190 , People's Republic of China.
University of Chinese Academy of Sciences , No. 19, Yuquan Road , Shijingshan District, Beijing 100049 , People's Republic of China.
Langmuir. 2019 Feb 26;35(8):3031-3037. doi: 10.1021/acs.langmuir.8b04187. Epub 2019 Feb 12.
Bacterial infection on biomaterial devices and the subsequent medical risks pose a serious problem in both human healthcare and industrial applications, resulting in a prevalence of various antimicrobial materials. Cationic amphiphilic polymer has been proposed to be a new generation of efficient antibacterial material, but the surface modified by such types of polymers still shows incomplete bactericidal ability and easily contaminated performance. With this in mind, a novel kind of geminized cationic amphiphilic polymer brush surface has been developed in this study, presenting a complete antibacterial activity, because of the synergistic biocidal effect of electrostatic and hydrophobic interactions, as well as the minimized contact area between bacteria and polymer surface. A structure self-adjustment process of polymer brush construction has been proposed, in which the mutual interference among cationic head groups can be avoided and the electrostatic repulsion and hydrophobic attraction can be balanced, in the formation of a smooth and tight surface. A self-cleaning capability of polymer surface has been performed via hydrolysis and degradation, maintaining a high antibacterial activity. Therefore, we provide a facile and possible manipulation strategy to fabricate super-antibacterial and self-cleaning surfaces in a wide range of biomedical and industrial applications.
生物材料装置上的细菌感染以及由此产生的各种医学风险，在人类医疗保健和工业应用中都是一个严重的问题，这导致了各种抗菌材料的广泛应用。阳离子两亲聚合物已被提议作为新一代高效抗菌材料，但经过此类聚合物表面修饰的材料仍表现出不完全的杀菌能力和易被污染的性能。有鉴于此，本研究开发了一种新型的双阳离子两亲聚合物刷状表面，由于静电和疏水相互作用的协同杀菌作用以及细菌与聚合物表面之间接触面积的最小化，呈现出完全的抗菌活性。提出了一种聚合物刷结构的自调整过程，其中可以避免阳离子头基之间的相互干扰，并可以平衡静电排斥和疏水吸引，从而形成光滑而紧密的表面。聚合物表面通过水解和降解具有自清洁能力，保持了高的抗菌活性。因此，我们提供了一种简单且可行的操作策略，可在广泛的生物医学和工业应用中制造超抗菌和自清洁表面。
