局部翻译与线粒体的串扰：为轴突和树突可塑性提供动力。
Crosstalk of Local Translation and Mitochondria: Powering Plasticity in Axons and Dendrites.
机构信息
Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA.
出版信息
Neuron. 2019 Jan 16;101(2):204-206. doi: 10.1016/j.neuron.2018.12.027.
Two papers in Cell uncover reciprocal crosstalk of local translation and mitochondria in neurons. Rangaraju et al. (2019) observe tethered compartments of stable mitochondria in dendrites that provide a local energy supply for mRNA translation at synapses. Cioni et al. (2019) report a novel association of axonal RNA granules with Rab7a-late endosomes that provides a platform for local translation supporting mitochondria.
两篇发表在《细胞》上的论文揭示了神经元中局部翻译和线粒体的相互交流。Rangaraju 等人（2019 年）观察到树突中稳定的线粒体被束缚在隔间内，为突触处的 mRNA 翻译提供局部能量供应。Cioni 等人（2019 年）报告了一个新的轴突 RNA 颗粒与 Rab7a 晚期内体的关联，为支持线粒体的局部翻译提供了一个平台。
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