Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Cyclotron Research Center, Research Institute of Clinical Medicine, Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea.
Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Cyclotron Research Center, Research Institute of Clinical Medicine, Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea.
J Photochem Photobiol B. 2019 Mar;192:1-7. doi: 10.1016/j.jphotobiol.2019.01.003. Epub 2019 Jan 9.
As a new light source, light emitting diode (LED) with high brightness and lower cost has been rapidly developed in medical application and light therapy. LED phototherapy can activate target cells with appropriate power and adequate energy density. This review provides general information on therapeutic applications of blue, green, yellow, red, and infrared LED in medical treatments for various physical abnormalities and on bio-imaging. The bio-imaging system is improved by decreasing the number of microscopes apparatuses including neutral-density filter, excitation filters and mechanical shutters. The numbers of excitation photons are increased and the fluorescent excitation efficiency is improved at cellular level. In the target tissue, the therapeutic effect of LEDs is dependent on incident photons irrespective of the system used to generate these photons. Photomodulated light from LED device is delivered in pulsed mode with specific pulse sequences and time. Too low or too high dose of energy may be ineffective at all. Clinical applications of LED light depending on different wavelengths are summarized. The author's photo-oncomic experiments using a specific blue light emitting diode were introduced, showing that blue LED possessed anti-proliferative and anti-metastatic abilities in cancer cells and mice. As a promising light source, photo-oncomic approach of blue LED could be applied to treat cancers and inflammatory diseases.
作为一种新型光源，高亮度、低成本的发光二极管（LED）在医学应用和光疗中得到了迅速发展。LED 光疗可以用适当的功率和足够的能量密度激活靶细胞。本文综述了蓝、绿、黄、红和红外 LED 在治疗各种物理异常和生物成像方面的治疗应用。通过减少包括中性密度滤光片、激发滤光片和机械快门在内的显微镜设备数量，生物成像系统得到了改善。在细胞水平上，增加了激发光子的数量，并提高了荧光激发效率。在目标组织中，LED 的治疗效果取决于入射光子，而与产生这些光子的系统无关。LED 设备发出的光调制光以特定的脉冲序列和时间以脉冲模式传输。能量太低或太高都可能完全无效。总结了基于不同波长的 LED 光的临床应用。作者介绍了使用特定的蓝光发光二极管进行的光致癌实验，结果表明蓝光 LED 在癌细胞和小鼠中具有抗增殖和抗转移能力。作为一种有前途的光源，蓝光 LED 的光致癌方法可用于治疗癌症和炎症性疾病。
