Melewski D J, Higby D J, Reese P A
Department of Medical Oncology, Roswell Park Memorial Institute, Buffalo, NY 14263.
J Med. 1988;19(1):1-11.
Thirty-four patients undergoing bone marrow transplantation or remission induction for acute non-lymphocytic leukemia were the subjects of a study to determine whether outcome of infection (survival, death) could be related to total complement (TC), complement components, or C-reactive protein (CRP). Serum samples were obtained when the neutropenic patients became febrile, and at intervals thereafter. Significant differences were found between final total serum complement levels, the C3 component of complement, and the C-reactive protein. Multivariate logistic regression demonstrated a significant relationship between the final C3 complement and C-reactive protein levels and the outcome of infection. Changes between initial and final values were also predictive of outcome, suggesting that the magnitude and direction of changes in these measurements may assist the clinician in assessing the success of his prescribed antibiotic therapy. Our data suggest that a test battery comprising serial TC, C3, and CRP measurements may have more predictive potential than each test performed independently.
34例接受骨髓移植或急性非淋巴细胞白血病缓解诱导治疗的患者参与了一项研究，以确定感染结局（生存、死亡）是否与总补体（TC）、补体成分或C反应蛋白（CRP）有关。当中性粒细胞减少的患者发热时采集血清样本，并在其后定期采集。最终血清总补体水平、补体C3成分和C反应蛋白之间存在显著差异。多因素逻辑回归显示，最终C3补体和C反应蛋白水平与感染结局之间存在显著关系。初始值与最终值之间的变化也可预测结局，这表明这些测量值变化的幅度和方向可能有助于临床医生评估其规定的抗生素治疗的成功与否。我们的数据表明，一套包含连续TC、C3和CRP测量值的检测可能比单独进行的每项检测具有更大的预测潜力。
