Centre for Pain Research, School of Clinical and Applied Sciences, Portland Way, Leeds Beckett University, Leeds, LS1 3HE, UK.
MENA Research Group, School of Clinical and Applied Sciences, Leeds Beckett University, Leeds, UK.
BMC Public Health. 2019 Jan 17;19(1):78. doi: 10.1186/s12889-018-6374-9.
Painful Diabetic Neuropathy (PDN) is a complication that affects up to one third of people living with diabetes. There is limited data on the prevalence of PDN from countries in the Middle East and North Africa. The aim of this study was to estimate the point prevalence of PDN in adults in Eastern Libya using the self-report Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) pain scale.
We invited patients attending the Benghazi Diabetes Centre who had diabetes for ≥ 5 years to take part in the study. Patients provided consent and completed the Arabic S-LANSS. Anthropometrics, marital status, socioeconomic and education information was recoded and fasting plasma glucose concentration determined.
Four hundred and fifty participants completed the study (age = 19 to 87 years, BMI = 17.6 to 44.2 kg/m, 224 women). One hundred and ninety five participants (43.3%) reported pain in their lower limbs in the previous 6 months and 190/195 participants (97.4%) reported a S-LANSS score of ≥ 12 suggesting they had neuropathic pain characteristics. Thus, 42.2% (190/450) of participants with diabetes were categorised as experiencing pain with neuropathic characteristics. Mean ± SD duration of diabetes for participants with PDN (20.4 ± 6.5 years) was significantly higher compared with those without PDN (11.1 ± 4.6 years). Participants with PDN smoked tobacco for more years than those without pain (7.9 ± 12.3 years versus 1.1 ± 3.9 years respectively); had significantly higher fasting plasma glucose concentration (143.6 ± 29.3 mg/dl versus 120.0 ± 17.3 mg/dl) and had a significantly higher levels of education and employment status. The most significant predictors of PDN were duration of diabetes (OR = 25.85, 95% CI = 13.56-49.31), followed by smoking for men (OR = 8.28, 95% CI = 3.53-9.42), obesity (OR = 3.96, 95% CI = 2.25-6.96) and high fasting plasma glucose concentration (OR = 3.51, 95% CI = 1.99-6.21).
The prevalence of PDN in people with diabetes in Eastern Libya was 42.2%. Risk factors for developing PDN were high fasting plasma glucose concentration, long duration of diabetes, and higher level of educational and employment status.
疼痛性糖尿病周围神经病变（PDN）是一种影响多达三分之一糖尿病患者的并发症。中东和北非国家有关 PDN 患病率的数据有限。本研究的目的是使用自我报告的利兹周围神经病变症状和体征（S-LANSS）疼痛量表评估利比亚东部成年人 PDN 的时点患病率。
我们邀请了在班加西糖尿病中心就诊且糖尿病病程≥5 年的患者参加这项研究。患者提供同意并完成了阿拉伯语 S-LANSS 评估。记录人体测量学、婚姻状况、社会经济和教育信息，并测定空腹血浆葡萄糖浓度。
450 名参与者完成了这项研究（年龄 19 至 87 岁，BMI 为 17.6 至 44.2kg/m2，224 名女性）。195 名参与者（43.3%）报告在过去 6 个月内下肢有疼痛，190/195 名参与者（97.4%）报告 S-LANSS 评分≥12，提示他们具有神经病理性疼痛特征。因此，450 名糖尿病患者中有 42.2%（190/450）被归类为有神经病理性疼痛特征的疼痛。有 PDN 的参与者的糖尿病病程的平均值±标准差为 20.4±6.5 年，明显高于无 PDN 的参与者（11.1±4.6 年）。有 PDN 的参与者吸烟的年限多于无疼痛的参与者（7.9±12.3 年与 1.1±3.9 年）；空腹血浆葡萄糖浓度显著更高（143.6±29.3mg/dl 与 120.0±17.3mg/dl），教育和就业水平也显著更高。PDN 的最显著预测因素是糖尿病病程（OR=25.85，95%CI=13.56-49.31），其次是男性吸烟（OR=8.28，95%CI=3.53-9.42）、肥胖（OR=3.96，95%CI=2.25-6.96）和高空腹血浆葡萄糖浓度（OR=3.51，95%CI=1.99-6.21）。
利比亚东部糖尿病患者中 PDN 的患病率为 42.2%。发生 PDN 的风险因素是高空腹血浆葡萄糖浓度、糖尿病病程长，以及更高的教育和就业水平。
