Aslam Amir, Singh Jaipaul, Rajbhandari Satyan
Department of Diabetes, Lancashire Teaching Hospital NHS Trust, Chorley and South Ribble District General Hospital, Preston Road, Chorley PR7 1PP, UK.
School of Pharmacy and Biomedical Sciences and School of Forensic and Investigative Sciences, University of Central Lancashire, Preston, Lancashire PR1 2HE, UK.
Pain Res Treat. 2014;2014:412041. doi: 10.1155/2014/412041. Epub 2014 May 6.
The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. It has a huge effect on a person's daily life, both physically and mentally. Despite huge advances in diabetes and neurology, the exact mechanism of pain causation in PDN is still not clear. The origin of pain could be in the peripheral nerves of the central nervous system. In this review, we discuss various possible mechanisms of the pathogenesis of pain in PDN. We discuss the role of hyperglycaemia in altering the physiology of peripheral nerves. We also describe central mechanisms of pain.
全球糖尿病患病率正在上升，其相关并发症也随之增加。疼痛性糖尿病神经病变（PDN）是糖尿病一种众所周知的并发症，也是所有神经性疼痛最常见的原因。约三分之一的糖尿病患者患有PDN。它对一个人的日常生活在身体和心理方面都有巨大影响。尽管糖尿病和神经学取得了巨大进展，但PDN疼痛的确切发病机制仍不清楚。疼痛的起源可能在于中枢神经系统的外周神经。在本综述中，我们讨论了PDN疼痛发病机制的各种可能机制。我们讨论了高血糖在改变外周神经生理学方面的作用。我们还描述了疼痛的中枢机制。
