Division of Hematology, Duke University Medical Center, Durham, NC.
Blood. 2019 Feb 28;133(9):902-905. doi: 10.1182/blood-2018-11-876839. Epub 2019 Jan 17.
Recent multistate outbreaks of coagulopathy caused by brodifacoum-tainted synthetic cannabinoids or "fake weed" highlight the public health impact of long-acting anticoagulant rodenticides (LAARs). Patients presenting with this syndrome have had recent exposure to synthetic cannabinoids, evidence of isolated vitamin K antagonism with or without bleeding, and detectable levels of brodifacoum and other LAARs in circulation. This article will provide information on synthetic cannabinoids, LAARs, and coagulopathic manifestations arising from use of adulterated synthetic cannabinoids and their management.
最近由污染了溴敌隆的合成大麻素或“假草”引起的多州暴发的凝血功能障碍事件突显了长效抗凝血灭鼠剂（LAARs）对公众健康的影响。出现这种综合征的患者最近接触过合成大麻素，有孤立的维生素 K 拮抗剂存在的证据，伴有或不伴有出血，并且在循环中检测到溴敌隆和其他 LAARs。本文将提供有关合成大麻素、LAARs 以及由掺假合成大麻素使用引起的凝血功能障碍表现及其管理的信息。
