Khayat Wujood, Lehmann Christian
Department of Physiology and Biophysics, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah 21423, Saudi Arabia.
Metabolites. 2022 Jun 14;12(6):541. doi: 10.3390/metabo12060541.
Abnormal blood coagulation or coagulopathy is a common manifestation of many pathological conditions. It occurs when there is an imbalance between the activities of the coagulation system and the fibrinolytic system, leading to excessive or impaired intravascular blood clot formation, which can disturb blood flow causing ischemia or hemorrhage in the affected tissues. A growing body of evidence has demonstrated blood coagulation abnormalities in association with cannabinoid use, suggesting the involvement of the endogenous cannabinoid system (ECS) in modulating blood coagulation. However, the evidence in the literature has been controversial on whether cannabinoids promote or inhibit blood coagulation. The ECS has been extensively studied in recent years for its potential as a therapeutic target for many diseases. This review provides a brief introduction to the ECS and discusses the reported anticoagulatory and procoagulatory effects of various cannabinoids, highlighting some possible mechanisms that might underlie the observed effects. Understanding the coagulatory effects of cannabinoids and the interaction between the coagulation system and the ECS is vital for developing novel therapeutics for coagulopathies.
异常血液凝固或凝血病是许多病理状况的常见表现。当凝血系统和纤维蛋白溶解系统的活性失衡时就会发生这种情况，导致血管内血液凝块形成过多或受损，进而扰乱血流，在受影响的组织中引起缺血或出血。越来越多的证据表明，使用大麻素与血液凝固异常有关，这表明内源性大麻素系统（ECS）参与调节血液凝固。然而，文献中的证据对于大麻素是促进还是抑制血液凝固一直存在争议。近年来，ECS因其作为许多疾病治疗靶点的潜力而受到广泛研究。本综述简要介绍了ECS，并讨论了各种大麻素已报道的抗凝和促凝作用，强调了可能是观察到的作用基础的一些潜在机制。了解大麻素的凝血作用以及凝血系统与ECS之间的相互作用对于开发治疗凝血病的新型疗法至关重要。
