微小RNA-506通过靶向人膀胱癌中的RWDD4抑制细胞增殖、侵袭、迁移及上皮-间质转化。
MiR-506 inhibits cell proliferation, invasion, migration and epithelial-to-mesenchymal transition through targeting RWDD4 in human bladder cancer.
作者信息
Hou Yi
机构信息
Department of Urology, The Fourth People's Hospital of Shenyang, Shenyang, Liaoning 110031, P.R. China.
出版信息
Oncol Lett. 2019 Jan;17(1):73-78. doi: 10.3892/ol.2018.9594. Epub 2018 Oct 18.
Abstract
MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell proliferation, migration and invasion. Additionally, upregulated miR-506 increased E-cadherin, and reduced N-cadherin and Vimentin expression levels, as markers of epithelial-to-mesenchymal transition. RWD domain containing 4 (RWDD4) was revealed to be a miR506 target in BCa cells, and the downregulation of RWDD4 was found to suppress BCa cell proliferation, migration and invasion. In summary, miR-506 may suppress the aggressive properties of human BCa cells by targeting RWDD4, and thus may be a novel therapeutic target in human BCa.
摘要
微小RNA（MiR）-506在多种癌症中发挥着至关重要的作用。然而，miR-506在膀胱癌（BCa）进展中的作用仍有待研究。本研究表明，miR-506在BCa组织和细胞系中的表达下调。同时，miR-506的过表达抑制了细胞增殖、迁移和侵袭。此外，上调的miR-506增加了E-钙黏蛋白，并降低了作为上皮-间质转化标志物的N-钙黏蛋白和波形蛋白的表达水平。含RWD结构域蛋白4（RWDD4）被发现是BCa细胞中的miR-506靶点，并且发现RWDD4的下调可抑制BCa细胞的增殖、迁移和侵袭。总之，miR-506可能通过靶向RWDD4抑制人BCa细胞的侵袭性，因此可能是人类BCa的一个新的治疗靶点。
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