Hou Yi
Department of Urology, The Fourth People's Hospital of Shenyang, Shenyang, Liaoning 110031, P.R. China.
Oncol Lett. 2019 Jan;17(1):73-78. doi: 10.3892/ol.2018.9594. Epub 2018 Oct 18.
MicroRNA (MiR)-506 serves a vital role in several types of cancer. However, the role of miR-506 in bladder cancer (BCa) progression remains to be investigated. The present study demonstrated that miR-506 expression was downregulated in BCa tissues and cell lines. Meanwhile, overexpression of miR-506 inhibited cell proliferation, migration and invasion. Additionally, upregulated miR-506 increased E-cadherin, and reduced N-cadherin and Vimentin expression levels, as markers of epithelial-to-mesenchymal transition. RWD domain containing 4 (RWDD4) was revealed to be a miR506 target in BCa cells, and the downregulation of RWDD4 was found to suppress BCa cell proliferation, migration and invasion. In summary, miR-506 may suppress the aggressive properties of human BCa cells by targeting RWDD4, and thus may be a novel therapeutic target in human BCa.
微小RNA（MiR）-506在多种癌症中发挥着至关重要的作用。然而，miR-506在膀胱癌（BCa）进展中的作用仍有待研究。本研究表明，miR-506在BCa组织和细胞系中的表达下调。同时，miR-506的过表达抑制了细胞增殖、迁移和侵袭。此外，上调的miR-506增加了E-钙黏蛋白，并降低了作为上皮-间质转化标志物的N-钙黏蛋白和波形蛋白的表达水平。含RWD结构域蛋白4（RWDD4）被发现是BCa细胞中的miR-506靶点，并且发现RWDD4的下调可抑制BCa细胞的增殖、迁移和侵袭。总之，miR-506可能通过靶向RWDD4抑制人BCa细胞的侵袭性，因此可能是人类BCa的一个新的治疗靶点。
