Iemoto Takao, Nishiumi Shin, Kobayashi Takashi, Fujigaki Seiji, Hamaguchi Tetsuya, Kato Ken, Shoji Hirokazu, Matsumura Yasuhiro, Honda Kazufumi, Yoshida Masaru
Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
Division of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Oncol Lett. 2019 Jan;17(1):831-842. doi: 10.3892/ol.2018.9731. Epub 2018 Nov 19.
The survival times of patients with advanced colorectal cancer (CRC) have increased due to the introduction of chemotherapy involving irinotecan and cetuximab. However, further studies are required on the effective pretreatment methods for identifying patients with CRC who would respond to particular treatments. The aim of the present study was to identify biomarkers for predicting the efficacy of chemotherapy for CRC. A total of 123 serum samples were collected from 31 patients with CRC just prior to each of the first four rounds of chemotherapy. Serum metabolome analysis was performed using a multiplatform metabolomics system, and univariate Cox regression hazards analysis of the time to disease progression was conducted. Octanoic acid and 1,5-anhydro-D-glucitol were identified as biomarker candidates. In addition, the serum level of octanoic acid was indicated to be significantly associated with the time to disease progression (hazard ratio, 3.3; 95% confidence interval, 1.099-11.840; P=0.033). The serum levels of fatty acids, in particular polyunsaturated fatty acids, tended to be downregulated in the partial response group. The findings of the present study suggest that the serum level of octanoic acid may serve as a useful predictor for the prognosis of CRC.
由于引入了包含伊立替康和西妥昔单抗的化疗，晚期结直肠癌（CRC）患者的生存时间有所延长。然而，对于识别对特定治疗有反应的CRC患者的有效预处理方法，仍需进一步研究。本研究的目的是确定预测CRC化疗疗效的生物标志物。在31例CRC患者的前四轮化疗前，分别采集了123份血清样本。使用多平台代谢组学系统进行血清代谢组分析，并对疾病进展时间进行单变量Cox回归风险分析。辛酸和1,5-脱水-D-葡萄糖醇被确定为生物标志物候选物。此外，辛酸的血清水平与疾病进展时间显著相关（风险比，3.3；95%置信区间，1.099-11.840；P=0.033）。在部分缓解组中，脂肪酸尤其是多不饱和脂肪酸的血清水平往往下调。本研究结果表明，辛酸的血清水平可能作为CRC预后的有用预测指标。
