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本文引用的文献

1
Long non-coding RNA MIAT promotes gastric cancer growth and metastasis through regulation of miR-141/DDX5 pathway.长链非编码 RNA MIAT 通过调控 miR-141/DDX5 通路促进胃癌生长和转移。
J Exp Clin Cancer Res. 2018 Mar 14;37(1):58. doi: 10.1186/s13046-018-0725-3.
2
miR-340 alleviates chemoresistance of osteosarcoma cells by targeting ZEB1.微小RNA-340通过靶向锌指E盒结合蛋白1减轻骨肉瘤细胞的化疗耐药性。
Anticancer Drugs. 2018 Jun;29(5):440-448. doi: 10.1097/CAD.0000000000000614.
3
Long non-coding RNA MIAT promotes breast cancer progression and functions as ceRNA to regulate DUSP7 expression by sponging miR-155-5p.长链非编码RNA MIAT通过海绵吸附miR-155-5p促进乳腺癌进展并作为竞争性内源RNA调控DUSP7表达。
Oncotarget. 2017 Jul 12;8(44):76153-76164. doi: 10.18632/oncotarget.19190. eCollection 2017 Sep 29.
4
Long noncoding RNA ZEB1-AS1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB1.长链非编码RNA ZEB1-AS1通过表观遗传激活ZEB1在骨肉瘤中发挥癌基因作用。
Am J Transl Res. 2016 Oct 15;8(10):4095-4105. eCollection 2016.
5
The role of epigenetics and long noncoding RNA MIAT in neuroendocrine prostate cancer.表观遗传学和长链非编码RNA MIAT在神经内分泌前列腺癌中的作用。
Epigenomics. 2016 May;8(5):721-31. doi: 10.2217/epi.16.6. Epub 2016 Apr 20.
6
Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts.在瘢痕疙瘩成纤维细胞中，lncRNA-ATB的敲低通过miR-200c靶向ZNF217来抑制TGF-β2的自分泌分泌。
Sci Rep. 2016 Apr 19;6:24728. doi: 10.1038/srep24728.
7
Long Non-Coding RNA ucoo2kmd.1 Regulates CD44-Dependent Cell Growth by Competing for miR-211-3p in Colorectal Cancer.长链非编码RNA ucoo2kmd.1通过竞争结合miR-211-3p调控结直肠癌中CD44依赖的细胞生长
PLoS One. 2016 Mar 14;11(3):e0151287. doi: 10.1371/journal.pone.0151287. eCollection 2016.
8
Sirt1 AS lncRNA interacts with its mRNA to inhibit muscle formation by attenuating function of miR-34a.Sirt1反义长链非编码RNA与它的信使核糖核酸相互作用，通过减弱微小核糖核酸-34a的功能来抑制肌肉形成。
Sci Rep. 2016 Feb 23;6:21865. doi: 10.1038/srep21865.
9
microRNA-150 promotes cervical cancer cell growth and survival by targeting FOXO4.微小RNA-150通过靶向FOXO4促进宫颈癌细胞的生长和存活。
BMC Mol Biol. 2015 Dec 29;16:24. doi: 10.1186/s12867-015-0052-6.
10
MIR-150 promotes prostate cancer stem cell development via suppressing p27Kip1.微小RNA-150通过抑制p27Kip1促进前列腺癌干细胞的发育。
Eur Rev Med Pharmacol Sci. 2015 Nov;19(22):4344-52.

长链非编码RNA MIAT通过竞争性结合miR-150-5p来调控骨肉瘤中ZEB1的表达。

Long non-coding RNA MIAT competitively binds miR-150-5p to regulate ZEB1 expression in osteosarcoma.

作者信息

Jin Hao, Jin Xin, Chai Weiguang, Yin Zhiqiang, Li Yang, Dong Feng, Wang Wenbo

机构信息

Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150006, P.R. China.

出版信息

Oncol Lett. 2019 Jan;17(1):1229-1236. doi: 10.3892/ol.2018.9671. Epub 2018 Nov 7.

DOI:10.3892/ol.2018.9671
PMID:30655889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6312950/
Abstract

Long non-coding RNAs (LncRNAs), are significant in a number of biological stages and illnesses. The myocardial infarction associated transcript (MIAT) serves a function in numerous types of illness and physiological and pathological processes, including paranoid schizophrenia, diabetic retinopathy, myocardial infarction and neuroendocrine prostate cancer. However, the function of the lncRNA MIAT in the development of osteosarcoma is unknown. It has been identified that during the development of osteosarcoma, MIAT is upregulated in tumor tissues compared to adjacent non-tumor tissues. The spreading and proliferation of osteosarcoma cells was reduced by MIAT knockdown. These findings indicate that MIAT functions by competing with critical RNAs to target miR-150-5p and activate zinc finger E-box binding homeobox 1 to modulate the function of osteosarcoma cells. Together, the present findings may contribute to the understanding of the pathogenesis of osteosarcoma.

摘要

长链非编码RNA（LncRNAs）在许多生物学阶段和疾病中具有重要意义。心肌梗死相关转录本（MIAT）在多种疾病以及生理和病理过程中发挥作用，包括偏执型精神分裂症、糖尿病视网膜病变、心肌梗死和神经内分泌前列腺癌。然而，lncRNA MIAT在骨肉瘤发生发展中的作用尚不清楚。现已确定，在骨肉瘤发生过程中，与相邻非肿瘤组织相比，MIAT在肿瘤组织中表达上调。敲低MIAT可减少骨肉瘤细胞的扩散和增殖。这些发现表明，MIAT通过与关键RNA竞争来靶向miR-150-5p并激活锌指E盒结合同源框1，从而调节骨肉瘤细胞的功能。总之，目前的研究结果可能有助于理解骨肉瘤的发病机制。