Division of Endocrinology Erasmus Hospital Université Libre de Bruxelles Brussels Belgium.
ULB Center for Diabetes Research Université Libre de Bruxelles Brussels Belgium.
Ann Clin Transl Neurol. 2018 Nov 25;6(1):161-166. doi: 10.1002/acn3.686. eCollection 2019 Jan.
Diabetes is a common complication of Friedreich ataxia, requiring sensitive diagnostic methods. Here, we compared the performance of different tests that assess glucose tolerance, insulin sensitivity, and -cell function in Friedreich ataxia patients, heterozygous mutation carriers and controls. We find that diabetes is underdiagnosed with fasting glucose alone. The oral glucose tolerance test (OGTT) provides 1.2- to 3.5-fold more diagnoses of impaired glucose homeostasis and diabetes, and adequately measures insulin sensitivity, insulin secretion, and -cell function. Clinicians in charge of Friedreich ataxia patients and researchers should incorporate the OGTT as an accurate diagnostic and research tool.
糖尿病是弗里德里希共济失调的常见并发症，需要敏感的诊断方法。在这里，我们比较了评估葡萄糖耐量、胰岛素敏感性和 -细胞功能的不同测试在弗里德里希共济失调患者、杂合子突变携带者和对照组中的表现。我们发现仅通过空腹血糖检查会导致糖尿病漏诊。口服葡萄糖耐量试验（OGTT）提供了 1.2 到 3.5 倍更多的葡萄糖稳态受损和糖尿病的诊断，并能充分测量胰岛素敏感性、胰岛素分泌和 -细胞功能。负责弗里德里希共济失调患者的临床医生和研究人员应将 OGTT 作为一种准确的诊断和研究工具。
