Department of Pharmacology, School of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200032, P.R. China.
Biomater Sci. 2019 Jan 29;7(2):461-471. doi: 10.1039/c8bm01340c.
Targeted drug delivery is emerging as a promising strategy to achieve better clinical outcomes. Actively targeted drug delivery that utilizes overexpressed receptors or antigens on diseased tissues is receiving increasing scrutiny, especially due to the uncertainty of existence of the enhanced permeability and retention (EPR) effect in cancer patients. Peptide ligands are advantageous over other classes of targeting ligands due to their accessibility of high-throughput screening, ease of synthesis, high specificity and affinity, etc. In this review, we briefly summarize the resources of peptide ligands and discuss the pitfalls and perspectives of peptide ligand-mediated targeted delivery of nanomedicines.
靶向药物递送作为一种很有前途的策略，正在出现，以实现更好的临床结果。主动靶向药物递送利用疾病组织中过表达的受体或抗原，受到越来越多的关注，特别是由于在癌症患者中增强的通透性和保留（EPR）效应的存在存在不确定性。与其他类别的靶向配体相比，肽配体具有优势，因为它们具有高通量筛选、易于合成、高特异性和亲和力等优点。在这篇综述中，我们简要总结了肽配体的资源，并讨论了肽配体介导的纳米药物靶向递释的陷阱和展望。
