Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France.
Org Biomol Chem. 2019 Feb 13;17(7):1683-1693. doi: 10.1039/c8ob02995d.
In recent years, a renewal of interest was shown to the quest for new synthetic solutions to directly introduce emergent fluorinated groups (SRf) onto molecules. In this context, a new generation of reagents (ArSO2SRf) as efficient sources of SCF3, SCF2H and more generally SRf groups, was designed. Hence, potent solutions were developed for the synthesis of SRf-containing molecules, compounds of interest for drug and agrochemical research. This review highlights the recent advances made in the synthesis and the use of this new class of reagents, considerably extending the portfolio of tools for the direct introduction of SRf moieties.
近年来，人们对寻求新的合成方法以直接将新兴的氟基团（SRf）引入分子中产生了新的兴趣。在这种情况下，设计了新一代试剂（ArSO2SRf）作为 SCF3、SCF2H 和更一般的 SRf 基团的有效来源。因此，为合成含 SRf 分子，即药物和农用化学品研究中的有价值化合物，开发了有效的方法。本文综述了这一新类试剂的合成和应用方面的最新进展，极大地扩展了直接引入 SRf 部分的工具组合。
