Xiong Heng-Ying, Pannecoucke Xavier, Besset Tatiana
Normandie Univ, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000, Rouen, France.
Chemistry. 2016 Nov 14;22(47):16734-16749. doi: 10.1002/chem.201603438. Epub 2016 Sep 13.
In recent years, much interest has been paid to difluoromethylthiolated molecules as the "SCF " moiety is a key motif in drug and agrochemical research. Consequently, the development of versatile strategies for the selective synthesis of SCF H- and SCF FG-containing molecules (FG=functional group) has attracted a lot of attention and inspired the scientific community to design new tools. This Minireview highlights the major progress made in this field. Particularly, methodologies developed for the difluoromethylation of sulfur-containing molecules and the direct construction of C-SCF bonds in various classes of compounds are showcased and discussed.
近年来，二氟甲基硫代化分子备受关注，因为“SCF”部分是药物和农用化学品研究中的关键基序。因此，开发用于选择性合成含SCFH和SCFFG（FG = 官能团）分子的通用策略引起了广泛关注，并激发科学界设计新工具。本综述强调了该领域取得的主要进展。特别展示并讨论了用于含硫分子二氟甲基化以及在各类化合物中直接构建C-SCF键的方法。
