Exercise Research Laboratory, School of Physical Education, Physical Therapy and Dance, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Department of Sports, School of Physical Education, Centro Universitário da Serra Gaúcha, Caxias do Sul, Brazil.
Aging Clin Exp Res. 2019 Nov;31(11):1573-1581. doi: 10.1007/s40520-019-01120-x. Epub 2019 Jan 18.
Aging is associated with a progressive decline in physical and neurophysiological functions, and some studies suggest that cerebral serotonin is decreased in older adults. These factors contribute to reduced ability to perform daily activities, influencing quality of life (QoL). Regular physical activity has demonstrated important benefits in reversing ageing effects; however, little is known whether different training protocols might induce differential effects on QoL. The aim of this study was to verify the effects of different types of training on QoL and its relation with plasma serotonin in healthy older women. Forty-eight older women were randomly assigned in four groups: Strength Training (ST), Endurance Training (ET), Combined Training (CT), and Control Group (CG) which was instructed not to engage in any physical exercise during the study time. Participants underwent 12 weeks of training twice a week. Plasma serotonin and a scoring system questionnaire SF-36 for evaluation of QoL were assessed at baseline and after the completion of training protocols. When comparing pre- and post-training periods all trained groups showed improvement in QoL, but the CT improved more domains. Plasma serotonin was significantly lower in the ST and in the CT groups in comparison with controls after the 12-week training. Significant correlations of plasma serotonin with physical functioning, role-physical, general health, vitality, and mental health were observed. CT resulted in higher amelioration in QoL, in comparison with ET or ST only. All training protocols induced significant reductions in peripheral serotonin levels, which were negatively correlated with improvements in QoL.
衰老是与身体和神经生理功能的逐渐下降相关的，一些研究表明，老年人的大脑血清素会减少。这些因素导致日常活动能力下降，影响生活质量 (QoL)。有研究表明，定期进行体育锻炼对逆转衰老的影响有重要作用；然而，我们对于不同的训练方案是否会对 QoL 产生不同的影响知之甚少。本研究旨在验证不同类型的训练对 QoL 的影响，以及其与健康老年女性血浆血清素的关系。48 名老年女性被随机分为四组：力量训练组（ST）、耐力训练组（ET）、综合训练组（CT）和对照组（CG），CG 在研究期间不进行任何体育锻炼。参与者每周进行两次，共 12 周的训练。在基线和训练方案完成后，评估了血浆血清素和 SF-36 评分系统问卷（用于评估 QoL）。与训练前相比，所有训练组在训练后 QoL 均有改善，但 CT 组在更多的领域得到了改善。与对照组相比，ST 和 CT 组在 12 周训练后血浆血清素明显降低。观察到血浆血清素与身体机能、身体角色、一般健康、活力和心理健康呈显著相关性。与 ET 或 ST 相比，CT 可使 QoL 得到更高的改善。所有训练方案均导致外周血清素水平显著降低，而 QoL 的改善与外周血清素水平的降低呈负相关。
