Department of Traditional Chinese Medicine, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Chin J Integr Med. 2019 May;25(5):386-394. doi: 10.1007/s11655-018-2579-0. Epub 2019 Jan 9.
Diabetic peripheral neuropathy (DPN) is a progressive neurodegenerative disease of peripheral nervous system with high energy requirement. The adenosine monophosphate-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor- γ coactivator 1 α (PGC-1 α) axis plays a key role in regulating mitochondrial energy metabolism. Increasing preclinical evidences have shown that inhibition of AMPK/PGC-1 α pathway leading to mitochondrial dysfunction in neurons or Schwann cells contributes to neuron apoptosis, distal axonopathy and nerve demyelination in DPN. Some Chinese medicine formulae or extracts from herbs may have potential neuroprotective effects on DPN via activating AMPK/PGC-1 α pathway and improving mitochondrial function.
糖尿病周围神经病变（DPN）是一种外周神经系统进行性神经退行性疾病，对能量的需求较高。一磷酸腺苷激活的蛋白激酶（AMPK）/过氧化物酶体增殖物激活受体-γ共激活因子 1α（PGC-1α）轴在调节线粒体能量代谢中起关键作用。越来越多的临床前证据表明，AMPK/PGC-1α 通路的抑制导致神经元或施万细胞中线粒体功能障碍，这有助于 DPN 中的神经元凋亡、远端轴突病变和神经脱髓鞘。一些中药方剂或草药提取物可能通过激活 AMPK/PGC-1α 通路和改善线粒体功能对 DPN 具有潜在的神经保护作用。
