AMPK 活性：治疗性植物化学物质预防糖尿病的主要靶点。
AMPK Activity: A Primary Target for Diabetes Prevention with Therapeutic Phytochemicals.
机构信息
Personalized Diet Research Group, Korea Food Research Institute, Jeonju 55365, Korea.
Department of Food Biotechnology, University of Science and Technology, Daejeon 34113, Korea.
出版信息
Nutrients. 2021 Nov 12;13(11):4050. doi: 10.3390/nu13114050.
Abstract
Diabetes is a metabolic syndrome characterized by inadequate blood glucose control and is associated with reduced quality of life and various complications, significantly shortening life expectancy. Natural phytochemicals found in plants have been traditionally used as medicines for the prevention of chronic diseases including diabetes in East Asia since ancient times. Many of these phytochemicals have been characterized as having few side effects, and scientific research into the mechanisms of action responsible has accumulated mounting evidence for their efficacy. These compounds, which may help to prevent metabolic syndrome disorders including diabetes, act through relevant intracellular signaling pathways. In this review, we examine the anti-diabetic efficacy of several compounds and extracts derived from medicinal plants, with a focus on AMP-activated protein kinase (AMPK) activity.
摘要
糖尿病是一种代谢综合征，其特征是血糖控制不足，与生活质量下降和各种并发症有关，显著缩短了预期寿命。自古以来，在东亚，人们一直将植物中发现的天然植物化学物质用作预防包括糖尿病在内的慢性疾病的药物。这些植物化学物质中有许多被认为副作用较小，对其作用机制的科学研究也积累了越来越多的证据证明其疗效。这些化合物可能有助于预防包括糖尿病在内的代谢综合征疾病，其作用机制是通过相关的细胞内信号通路。在这篇综述中，我们研究了几种源自药用植物的化合物和提取物的抗糖尿病功效，重点关注 AMP 激活的蛋白激酶 (AMPK) 活性。
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