Departamento de Morfologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais (UFMG), Avenida Presidente Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil.
Centro Universitário de Formiga, MG. Avenida Doutor Arnaldo de Senna, 328. Água, Vermelha, Formiga, MG, CEP 35570-000, Brazil.
Adv Rheumatol. 2018 Aug 3;58(1):21. doi: 10.1186/s42358-018-0022-z.
Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain associated to other symptoms, such as: fatigue, anxiety, depression and sleep disorders. Health education programs (HEP) have emerged as good non-pharmacological strategies to treat it. However, it is still not clear if the benefits are only subjective, or it has also objective impacts on immune and or neuroendocrine systems.
Fifty-eight fibromyalgia women were randomly allocated in experimental group (n = 27) or control group (n = 31). The experimental group was submitted to HEP treatment for 11 weeks, while control group did not receive intervention at the same period. All data were collected at zero and 11th week by a blinded researcher. The statistical analysis were made in GraphPad Prism software (version 5.0) with significant level adjusted for α = 0.05.
Forty-four patients concluded the full study, 21 in the experimental group and 23 in the control group. Intragroup and intergroup analysis revealed that treatment induced significant increases of IL-4 plasma levels, anti-inflammatory cytokine/inflammatory cytokine ratio (AC/IC ratio), salivary cortisol levels, in addition to significant decreases on FIQ scores. Intergroup variation analyses revealed also significant increases of IL-10 plasma levels.
The results presented suggest that this kind of HEP could induce subjective and objective changes (immune and neuroendocrine), that could explain, at least in part the improvement of fibromyalgia patient's health status. (Clinical Trial Registration Number - ReBEC - RBR-5tdnbr).
纤维肌痛（FM）是一种以广泛慢性疼痛为特征的综合征，伴有其他症状，如疲劳、焦虑、抑郁和睡眠障碍。健康教育计划（HEP）已成为治疗该病的良好非药物策略。然而，目前尚不清楚这些益处仅是主观的，还是对免疫和神经内分泌系统也有客观影响。
58 名纤维肌痛女性患者被随机分为实验组（n = 27）或对照组（n = 31）。实验组接受 HEP 治疗 11 周，而对照组在同一时期未接受干预。所有数据均由一名盲法研究人员在第 0 周和第 11 周收集。统计分析在 GraphPad Prism 软件（版本 5.0）中进行，调整显著性水平为α = 0.05。
44 名患者完成了完整的研究，实验组 21 名，对照组 23 名。组内和组间分析表明，治疗诱导了血浆 IL-4 水平、抗炎细胞因子/炎症细胞因子比值（AC/IC 比值）、唾液皮质醇水平的显著增加，同时 FIQ 评分显著降低。组间变异分析还显示血浆 IL-10 水平显著增加。
这些结果表明，这种 HEP 可能会引起主观和客观的变化（免疫和神经内分泌），这至少可以部分解释纤维肌痛患者健康状况的改善。（临床试验注册号 - ReBEC - RBR-5tdnbr）。
