消除人乳头瘤病毒和消除与 HPV 相关的疾病 - 全球公共卫生政策的科学依据。
Eradication of human papillomavirus and elimination of HPV-related diseases - scientific basis for global public health policies.
机构信息
a Department of Laboratory Medicine , Karolinska Institute , Stockholm , Sweden.
b Faculty of Social Sciences , University of Tampere , Tampere , Finland.
出版信息
Expert Rev Vaccines. 2019 Feb;18(2):153-160. doi: 10.1080/14760584.2019.1568876. Epub 2019 Feb 7.
INTRODUCTION
Infections with oncogenic human papillomaviruses (HPV) globally cause about 9% of cancers in females and 1% of cancers in males. HPV disease burden can be effectively controlled by prophylactic HPV-vaccination provided it has high impact.
AREAS COVERED
A unique series of biobank-based and health registry-based studies that exploit randomized intervention cohorts has provided data on population-level safety of HPV vaccination, duration of vaccine-induced protection and impact of gender-neutral HPV vaccination, providing a scientific basis for policies to eradicate oncogenic HPV types and associated diseases worldwide.
EXPERT COMMENTARY
The ultimate goal of HPV vaccination is the eradication of high-risk (hr) HPVs. Seventy-five percent coverage gender-neutral vaccination of early adolescents will rapidly eradicate also HPV16 from the general population.
简介
在全球范围内，致癌型人乳头瘤病毒（HPV）感染导致约 9%的女性癌症和 1%的男性癌症。通过预防性 HPV 疫苗接种可以有效控制 HPV 疾病负担，前提是疫苗具有高影响力。
涵盖领域
一系列独特的基于生物库和健康登记的研究利用随机干预队列提供了人群水平 HPV 疫苗接种安全性、疫苗诱导保护持续时间和性别中立 HPV 疫苗接种影响的数据，为全球消除致癌型 HPV 类型和相关疾病的政策提供了科学依据。
专家评论
HPV 疫苗接种的最终目标是根除高危型（hr）HPV。对青少年进行 75%覆盖率的性别中立疫苗接种将迅速从普通人群中根除 HPV16。
Zotero 插件