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对感染人乳头瘤病毒16型和18型的女性阴道微生物群的宏基因组学见解。

Metagenomic insight into the vaginal microbiome in women infected with HPV 16 and 18.

作者信息

Jung Da-Ryung, Choi Yeseul, Jeong Minsoo, Singh Vineet, Jeon Se Young, Seo Incheol, Park Nora Jee-Young, Lee Yoon Hee, Park Ji Young, Han Hyung Soo, Shin Jae-Ho, Chong Gun Oh

机构信息

Department of Applied Biosciences, Kyungpook National University, Daegu, Republic of Korea.

Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu, Republic of Korea.

出版信息

NPJ Biofilms Microbiomes. 2025 Jun 12;11(1):105. doi: 10.1038/s41522-025-00747-1.

DOI:10.1038/s41522-025-00747-1
PMID:40506497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12162855/
Abstract

Human papillomavirus (HPV) 16 and 18 (HPV 16/18) account for over 70% of cervical cancer (CC) cases, yet their interaction with the vaginal microbiome (VM) remains unclear. This study explored the association between high-risk HPV types (HR-HPVs), VM composition and bacterial function using shotgun metagenomic sequencing. In early-stage cervical lesions, the HPV 16/18 group showed reduced Lactobacillus-dominant community state types compared to other HR-HPVs, while invasive CC exhibited increased pathogenic bacteria, including Streptococcus agalactiae, Fannyhessea vaginae, and Sneathia vaginalis. The VM associated with HPV 16/18 was enriched in immune response and inflammation pathways, whereas other HR-HPVs were linked to cellular metabolism and hormonal signaling. Notably, HPV 16/18 exhibited stronger bacterial-fungal correlations, indicating shifts in the microbial community. Furthermore, 137 metagenome-assembled genomes provided insights into unique microbial genomic signatures. Our study links VM differences with HPV 16/18 oncogenic potential across cervical lesion stages, urging further research for better diagnostics and treatments.

摘要

人乳头瘤病毒（HPV）16型和18型（HPV 16/18）导致了超过70%的宫颈癌（CC）病例，但其与阴道微生物群（VM）的相互作用仍不清楚。本研究使用鸟枪法宏基因组测序探索了高危型HPV（HR-HPVs）、VM组成和细菌功能之间的关联。在早期宫颈病变中，与其他HR-HPVs相比，HPV 16/18组以乳酸杆菌为主导的群落状态类型减少，而浸润性CC中致病性细菌增加，包括无乳链球菌、阴道芬尼酵母菌和阴道斯内氏菌。与HPV 16/18相关的VM在免疫反应和炎症途径中富集，而其他HR-HPVs则与细胞代谢和激素信号传导有关。值得注意的是，HPV 16/18表现出更强的细菌-真菌相关性，表明微生物群落发生了变化。此外，137个宏基因组组装基因组为独特的微生物基因组特征提供了见解。我们的研究将VM差异与宫颈病变各阶段的HPV 16/18致癌潜力联系起来，促使进一步开展研究以实现更好的诊断和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/608889b8e00a/41522_2025_747_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/098ade040e79/41522_2025_747_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/8d34096195a8/41522_2025_747_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/4e73c66fefb7/41522_2025_747_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/608889b8e00a/41522_2025_747_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/098ade040e79/41522_2025_747_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/32c479ce6e51/41522_2025_747_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/9066a6d5b810/41522_2025_747_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/8d34096195a8/41522_2025_747_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/4e73c66fefb7/41522_2025_747_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1577/12162855/608889b8e00a/41522_2025_747_Fig6_HTML.jpg

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A multi-kingdom collection of 33,804 reference genomes for the human vaginal microbiome.一个包含 33804 个参考基因组的多王国集合，用于人类阴道微生物组。
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Temporal composition of the cervicovaginal microbiome associates with hrHPV infection outcomes in a longitudinal study.颈阴道微生物组的时间构成与纵向研究中 HPV 感染结果相关。
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