Gutiérrez-Vargas Rosaura, Velasco-Rojano Eduardo, Villasís-Keever Miguel Á, Portilla-Robertson Javier, Gutiérrez-Rodelo Araceli, Flores-Navarro Sonny, Juárez-Villegas Luis E, Zapata-Tarrés Marta
Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México, Ciudad de México. México.
Universidad Nacional Autónoma de México, Ciudad de México. México.
Bol Med Hosp Infant Mex. 2019;76(1):35-43. doi: 10.24875/BMHIM.18000146.
Oropharyngeal mucositis (OM) is one of the primary complications arising during oncological treatment, which significantly reduces the patient's quality of life (QoL). The aim of this study was to translate, culturally adapt, and validate the use of a new Spanish version of the Oropharyngeal Mucositis-Specific Quality-of-Life instrument (OMQoL) for pediatric patients.
A multicentric, cross-sectional validation study was conducted to translate and adapt OMQoL from English to Spanish for its use by children with OM aged 8-16 years. Reliability was measured using Cronbach's alpha; content and construct validity, in conjunction with exploratory factor analysis. The convergent validity, with the correlations of the scales for OM defined by the WHO, OMAS (Oropharingeal Mucositis Assessment Scale) and the PedsQL-3 cancer module in Spanish.
One hundred and ninety-three children with mean age of 10.91 ± 2.38 years participated in the study, out of which 101 (52.3%) were females. In this sample, 80 children (41.5%) suffered from acute lymphoblastic leukemia and 111 (57.5%) had grade 2 and 3 OM. The factorial analysis resulted in four dimensions with loads >0.40. Among the 31 items of the OMQoL, six were eliminated. Cronbach alpha of OMQoL-Spanish was 0.954. Spearman´s correlations (r) with the OMS and OMAS scales were significant (with r = -0.720 and r = -0.689; p < 0.01, respectively). Moderate correlation was observed with the PedsQL-3 cancer module (r = 0.426; p < 0.01).
OMQoL-Spanish demonstrated adequate psychometric properties, resulting in a reliable and valid instrument for measuring QoL in children with MO.
口腔黏膜炎（OM）是肿瘤治疗期间出现的主要并发症之一，它会显著降低患者的生活质量（QoL）。本研究的目的是翻译、进行文化调适并验证一种新的西班牙语版口腔黏膜炎特异性生活质量量表（OMQoL）在儿科患者中的应用。
开展了一项多中心横断面验证研究，将OMQoL从英语翻译并调适为西班牙语，供8至16岁的OM患儿使用。使用克朗巴哈系数测量信度；结合探索性因子分析评估内容效度和结构效度。通过与世界卫生组织定义的OM量表、OMAS（口腔黏膜炎评估量表）以及西班牙语版儿童生活质量量表-3癌症模块的相关性来评估收敛效度。
193名平均年龄为10.91±2.38岁的儿童参与了该研究，其中101名（52.3%）为女性。在这个样本中，80名儿童（41.5%）患有急性淋巴细胞白血病，111名（57.5%）患有2级和3级OM。因子分析得出四个维度，载荷>0.40。在OMQoL的31个条目中，有6个被剔除。西班牙语版OMQoL的克朗巴哈系数为0.954。与OMS和OMAS量表的斯皮尔曼相关性（r）显著（分别为r = -0.720和r = -0.689；p < 0.01）。与儿童生活质量量表-3癌症模块观察到中度相关性（r = 0.426；p < 0.01）。
西班牙语版OMQoL表现出足够的心理测量学特性，是一种用于测量MO患儿生活质量的可靠且有效的工具。
