State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmacy, Guangxi Normal University, Guilin, Guangxi 541004, China.
Chem Commun (Camb). 2019 Jan 31;55(11):1651-1654. doi: 10.1039/c8cc09359h.
We develop a novel peptide-based four-color fluorescent polydopamine nanoprobe for multiplexed sensing and imaging of tumor-related proteases in living cells. This nanoprobe responds rapidly and selectively, enabling simultaneous and high-contrast imaging of multiple proteases in living cells. Furthermore, it could detect the changes of protease expression in living cells.
我们开发了一种新型基于肽的四色荧光聚多巴胺纳米探针，用于在活细胞中对肿瘤相关蛋白酶进行多重传感和成像。该纳米探针具有快速和选择性响应的特点，能够同时对活细胞中的多种蛋白酶进行高对比度成像。此外，它还能够检测活细胞中蛋白酶表达的变化。
