Organic & Medicinal Chemistry Division , CSIR-Indian Institute of Chemical Biology , 4 Raja S. C. Mullick Road, Jadavpur , Kolkata - 700032 , West Bengal India.
Academy of Scientific and Innovative Research (AcSIR) , CSIR-Indian Institute of Chemical Biology Campus , 4 Raja S. C. Mullick Road , Kolkata 700 032 , India.
ACS Chem Neurosci. 2019 Mar 20;10(3):1118-1120. doi: 10.1021/acschemneuro.9b00002. Epub 2019 Jan 18.
In the past decade of research, drugs targeting amyloid beta (Aβ) have failed in clinical amelioration of Alzheimer's disease (AD). This has led to researchers searching for more attractive targets. Here, we discuss one such approach of developing future neurotherapeutics by targeting microtubules. Microtubules are the key structural and functional elements of neurons and have been found to be closely associated with neurodegenerative disorders like AD due to their association with tau. Tau is a microtubule associated protein whose abnormal phosphorylation leads to microtubule destabilization giving rise to variable tauopathies associated with different neurodegenerative disorders. Due to this association of microtubules with tau and their importance in neurons, microtubules can be considered as one of the important supplementary targets for designing future neurotherapeutics.
在过去十年的研究中，靶向淀粉样蛋白 β（Aβ）的药物未能改善阿尔茨海默病（AD）的临床症状。这导致研究人员寻找更有吸引力的靶点。在这里，我们讨论了一种通过靶向微管来开发未来神经治疗药物的方法。微管是神经元的关键结构和功能元素，由于与 tau 的关联，它们与 AD 等神经退行性疾病密切相关。Tau 是一种微管相关蛋白，其异常磷酸化导致微管不稳定，从而产生与不同神经退行性疾病相关的不同 tau 病。由于微管与 tau 的这种关联及其在神经元中的重要性，微管可以被视为设计未来神经治疗药物的重要辅助靶点之一。
