Department of Neurology, University of Alexandria, Alexandria, Egypt; Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Department of Radiology, Johns Hopkins University, Baltimore, MD, USA.
Mult Scler Relat Disord. 2019 Apr;29:15-22. doi: 10.1016/j.msard.2019.01.021. Epub 2019 Jan 10.
MOG antibody disease is an autoimmune disease of the central nervous system (CNS) characterized by the presence of a serological antibody against myelin oligodendrocyte glycoprotein (MOG). MRI is instrumental in distinguishing neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS), but MRI features of MOG disease appear to overlap with NMOSD and MS.
In this study we aim to characterize the radiological features of MOG antibody disease and compare the findings with those previously described.
This is a retrospective study of 26 MOG positive patients. We aim to describe their brain, spinal and orbital MRI features and compare our findings with those previously reported in the literature.
The majority of the abnormal findings was located on orbital MRIs, with more involvement of the anterior structures and bilateral involvement of the optic nerves. Brain abnormalities were distinct from both NMOSD and MS lesions. Spinal cord was the least affected.
This is a dedicated radiological study aiming to characterize the features of MOG antibody disease which might aid in the proper investigation of cases presenting with acquired demyelinating disorders.
MOG 抗体病是一种中枢神经系统（CNS）自身免疫性疾病，其特征是存在针对髓鞘少突胶质细胞糖蛋白（MOG）的血清抗体。MRI 有助于将视神经脊髓炎谱系疾病（NMOSD）与多发性硬化（MS）区分开来，但 MOG 病的 MRI 特征似乎与 NMOSD 和 MS 重叠。
本研究旨在描述 MOG 抗体病的影像学特征，并与以往描述的特征进行比较。
这是一项回顾性研究，共纳入 26 例 MOG 阳性患者。我们旨在描述他们的脑、脊髓和眼眶 MRI 特征，并将我们的发现与文献中以前报道的结果进行比较。
大多数异常发现位于眼眶 MRI 上，前结构受累更多，视神经双侧受累。脑异常与 NMOSD 和 MS 病变明显不同。脊髓受累最少。
这是一项专门的影像学研究，旨在描述 MOG 抗体病的特征，这可能有助于对表现为获得性脱髓鞘疾病的病例进行适当的检查。
