Shimada Ayaka, Suda Kenji, Nakano Eri, Tagawa Miho, Miyata Manabu, Kashii Satoshi, Hinoda Takuya, Fushimi Yasutaka, Kimura Kimitoshi, Nishigori Ryusei, Ahn Sinyeob, Grinstead John, Tsujikawa Akitaka
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo, Shimane, Japan.
Eye Brain. 2024 Oct 29;16:65-73. doi: 10.2147/EB.S474100. eCollection 2024.
To evaluate the use of delay alternating with nutation for tailored excitation-prepared T1-weighted turbo spin echo (DANTE T1-SPACE) imaging for diagnosing optic neuritis and to analyze its correlation with clinical findings before and after treatment.
Patients diagnosed with optic neuritis or non-arteritic anterior ischemic optic neuropathy (NA-AION) were evaluated at the Ophthalmology Department of Kyoto University Hospital. All patients underwent magnetic resonance (MR) studies before treatment initiation and ophthalmic examinations before and after treatment. Three ophthalmologists independently reviewed the MR scans for abnormalities. The magnetic resonance imaging (MRI) assessments included post-contrast DANTE T1-SPACE, post-contrast volumetric interpolated breath-hold examination (VIBE), and short T1 inversion recovery (STIR) scans. The presence of abnormalities in each sequence was determined.
Of 36 eyes from 30 patients, 21 eyes from 17 patients were diagnosed with optic neuritis, and 15 eyes from 13 patients were diagnosed with NA-AION. DANTE T1-SPACE sequences showed better sensitivity for detecting optic neuritis than STIR sequences (100% vs 67%, p = 0.009). VIBE images did not confirm enhancement of lesions in some cases with optic neuritis. No differences were observed among the sequences for NA-AION. Lesion length evaluated by DANTE T1-SPACE sequences was associated with circumpapillary retinal nerve fiber layer thickness at the initial visit, eye pain, and the time interval from symptom onset to MRI scan.
Contrast-enhanced DANTE T1-SPACE was better than other sequences of MRI for diagnosing optic neuritis.
评估交替延迟与章动的定制激发准备T1加权快速自旋回波（DANTE T1-SPACE）成像在诊断视神经炎中的应用，并分析其与治疗前后临床发现的相关性。
在京都大学医院眼科对诊断为视神经炎或非动脉性前部缺血性视神经病变（NA-AION）的患者进行评估。所有患者在开始治疗前接受磁共振（MR）检查，治疗前后接受眼科检查。三位眼科医生独立检查MR扫描以寻找异常。磁共振成像（MRI）评估包括对比剂增强后的DANTE T1-SPACE、对比剂增强后的容积内插屏气检查（VIBE）和短T1反转恢复（STIR）扫描。确定每个序列中异常的存在情况。
30例患者的36只眼中，17例患者的21只眼诊断为视神经炎，13例患者的15只眼诊断为NA-AION。DANTE T1-SPACE序列在检测视神经炎方面比STIR序列具有更高的敏感性（100%对67%，p = 0.009）。在一些视神经炎病例中，VIBE图像未证实病变有强化。对于NA-AION，各序列之间未观察到差异。通过DANTE T1-SPACE序列评估的病变长度与初诊时视乳头周围视网膜神经纤维层厚度、眼痛以及症状发作至MRI扫描的时间间隔相关。
对比剂增强的DANTE T1-SPACE在诊断视神经炎方面优于其他MRI序列。
