Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China; Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
Psychoneuroendocrinology. 2019 May;103:76-82. doi: 10.1016/j.psyneuen.2019.01.007. Epub 2019 Jan 9.
The prevalence of depression in the general population has risen sharply over the past few decades and has become a major health problem throughout the world. Increasing evidence suggests that inflammation plays an important role in the pathogenesis of depression. To better understand the role of inflammation in the pathogenesis of depression we can use the neutrophil-to-lymphocyte ratio (NLR) because it is a simple and effective marker of inflammation and immunity.
This cross-sectional study was conducted among adults from the healthy general population in Tianjin, China. NLR was measured according to the complete blood count. Depressive symptoms were assessed using the Zung Self-Rating Depression Scale (SDS), and a cutoff score of 45 was used to indicate the presence of depressive symptoms in the study participants. The relationship between NLR and the prevalence of depressive symptoms was evaluated separately for men and women using the multiple logistic regression analysis.
In the present study, the overall prevalence of depressive symptoms was 17.0% among all participants. In women, the multivariable-adjusted OR of having depressive symptoms was 1.28 (95% CI 1.10, 1.49; p for trend <0.01) for the fifth compared with the first quintile of NLR, and was 1.22 (95% CI 1.07,1.39; p < 0.01) per unit increase of NLR. However, no significant association was found between NLR and depressive symptoms in men.
This study suggests that increased NLR levels are independently related to depressive symptoms in women, but not in men. Further research is required to investigate this relationship with longitudinal data to establish the temporal ordering between these variables.
在过去几十年中，普通人群中的抑郁症患病率急剧上升，已成为全世界的一个主要健康问题。越来越多的证据表明，炎症在抑郁症的发病机制中起着重要作用。为了更好地理解炎症在抑郁症发病机制中的作用，我们可以使用中性粒细胞与淋巴细胞比值（NLR），因为它是炎症和免疫的简单而有效的标志物。
本横断面研究在中国天津的健康普通人群成年人中进行。根据全血细胞计数测量 NLR。使用zung 自评抑郁量表（SDS）评估抑郁症状，研究参与者中存在抑郁症状的截断分数为 45。使用多变量逻辑回归分析分别评估 NLR 与男性和女性抑郁症状患病率之间的关系。
在本研究中，所有参与者的抑郁症状总患病率为 17.0%。在女性中，与 NLR 的第一五分位相比，第五五分位的多变量调整 OR 为 1.28（95%CI 1.10,1.49;p 趋势<0.01），NLR 每增加一个单位，OR 为 1.22（95%CI 1.07,1.39;p<0.01）。然而，在男性中，NLR 与抑郁症状之间没有显著相关性。
本研究表明，较高的 NLR 水平与女性的抑郁症状独立相关，但与男性无关。需要进一步研究，使用纵向数据来研究这种关系，以确定这些变量之间的时间顺序。
