Zhang X C, Lyu Y B, Zhou J H, Chen C, Li C C, Cai J F, Cao Z J, Zhao F, Liu Y C, Gu H, Lu F, Shi X M
China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Beijing Municipal Health Commission Information Center/Beijing Municipal Health Commission Policy Research Center, Beijing 100034, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2021 Jan 6;55(1):25-30. doi: 10.3760/cma.j.cn112150-20200812-01112.
To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the risk of depression symptoms among older adults aged 65 and above in 9 longevity areas of China. Data was collected in 9 longevity areas of China from Healthy Aging and Biomarkers Cohort Study (HABCS) conducted between 2017 and 2018. Finally,2018 elderly aged 65 years and above with complete information on neutrophil count, lymphocyte count and depressive symptoms were included in this study. Information on demographic characteristics, lifestyle, and health status was collected through questionnaire and physical examination. Complete blood counts which included lymphocytes and neutrophils were obtained by testing venous blood samples. Participants were divided into four groups by the quartile of NLR level, i.e. , , , . Logistic regression model was applied to analyze the association of NLR with depression symptoms. Among 2 018 older adults, the mean(±SD) age was 82.6(±10.73), 1 032(51.14%) were male, 390(19.33%) were detected with depressive symptoms. Compared with participants of NLR in the 1 quartile, the (95%) of risk for depressive symptoms was 1.47 (0.99, 2.19), 1.67 (1.13, 2.47) and 1.95 (1.32, 2.89), respectively. Increased NLR level is significantly related to depressive symptoms among elderly aged 65 years and above in 9 longevity areas in China.
为研究中国9个长寿地区65岁及以上老年人中性粒细胞与淋巴细胞比值（NLR）与抑郁症状风险之间的关系。数据收集自2017年至2018年开展的中国健康老龄化与生物标志物队列研究（HABCS）中的9个长寿地区。最终，本研究纳入了2018名65岁及以上且中性粒细胞计数、淋巴细胞计数和抑郁症状信息完整的老年人。通过问卷调查和体格检查收集人口统计学特征、生活方式和健康状况信息。通过检测静脉血样本获得包含淋巴细胞和中性粒细胞的全血细胞计数。根据NLR水平的四分位数将参与者分为四组，即第一四分位数组、第二四分位数组、第三四分位数组、第四四分位数组。应用逻辑回归模型分析NLR与抑郁症状的关联。在2018名老年人中，平均（±标准差）年龄为82.6（±10.73）岁，男性1032名（51.14%），检测出抑郁症状者390名（19.33%）。与NLR处于第一四分位数的参与者相比，抑郁症状风险的比值比（95%置信区间）分别为1.47（0.99，2.19）、1.67（1.13，2.47）和1.95（1.32，2.89）。在中国9个长寿地区65岁及以上老年人中，NLR水平升高与抑郁症状显著相关。
