血清镁与外周动脉疾病的患病率：动脉粥样硬化风险在社区（ARIC）研究。

Serum magnesium and the prevalence of peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) study.

机构信息

Department of Cardiology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, China.

Department of Radiology, Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China.

出版信息

Atherosclerosis. 2019 Mar;282:196-201. doi: 10.1016/j.atherosclerosis.2018.12.004. Epub 2018 Dec 20.

DOI:10.1016/j.atherosclerosis.2018.12.004

PMID:30658844

Abstract

BACKGROUND AND AIMS

Peripheral arterial disease (PAD) is a clinical manifestation of extracoronary atherosclerosis. Many risk factors are involved in the process of PAD, but the association between serum magnesium (Mg) and PAD is not clear. Our study aimed to investigate whether serum Mg is associated with PAD incidence.

METHODS

A total of 13,826 participants (aged 40-64 years) in the Atherosclerosis Risk in Communities (ARIC) study (1987-1989) without prior PAD were included in the final analysis. Serum Mg levels were measured at visits 1 and 2. PAD was defined as an ankle brachial index less than 0.9, or hospitalization with a PAD diagnosis. Cox regression was used to calculate hazard ratios (HRs) for incidence of PAD and serum Mg.

RESULTS

During a median follow-up of 24.4 years, 1364 (48.4% female) PAD events were observed. After multiple adjustment, participants in the lowest (≤1.4 mEq/L) category of serum Mg compared with the highest (≥1.8 mEq/L) ones were at higher PAD risk (HR: 1.3; 95% confidence interval (CI): 1.06-1.58) (p value = 0.004). The HRs for PAD in 1.5, 1.6 and 1.7 mEq/L of serum Mg were 1.29 (95% CI: 1.08-1.54), 1.05 (95% CI: 0.89-1.24), and 1.0 (95% CI: 0.85-1.18), respectively.

CONCLUSIONS

Low serum Mg was independently associated with an increased prevalence of PAD in the large population-based study; further studies are needed to confirm our findings.

摘要

背景与目的

外周动脉疾病（PAD）是冠状动脉外动脉粥样硬化的临床表现。许多危险因素参与了 PAD 的发生过程，但血清镁（Mg）与 PAD 的关系尚不清楚。本研究旨在探讨血清 Mg 是否与 PAD 发生率有关。

方法

最终分析纳入了无既往 PAD 的动脉粥样硬化风险社区（ARIC）研究（1987-1989 年）中的 13826 名参与者（年龄 40-64 岁）。在访问 1 和 2 时测量血清 Mg 水平。PAD 定义为踝肱指数<0.9，或因 PAD 住院。Cox 回归用于计算 PAD 发生率和血清 Mg 的风险比（HR）。

结果

在中位随访 24.4 年期间，观察到 1364 例（48.4%为女性）PAD 事件。经多次调整后，与血清 Mg 最高（≥1.8 mEq/L）组相比，血清 Mg 最低（≤1.4 mEq/L）组的 PAD 风险更高（HR：1.3；95%置信区间（CI）：1.06-1.58）（p 值=0.004）。血清 Mg 为 1.5、1.6 和 1.7 mEq/L 时，PAD 的 HR 分别为 1.29（95% CI：1.08-1.54）、1.05（95% CI：0.89-1.24）和 1.0（95% CI：0.85-1.18）。