Wu Zhe, Ruan Zhishen, Liang Gang, Wang Xu, Wu Jianlin, Wang Bin
The First Clinical College, Shandong Chinese Medical University, Jinan, China.
Department of Vascular Surgery, The First Affiliated Hospital of Shandong Chinese Medical University, Jinan, China.
PLoS One. 2023 Aug 11;18(8):e0289973. doi: 10.1371/journal.pone.0289973. eCollection 2023.
Magnesium has been found to have a strong association with peripheral arterial disease (PAD), and dietary magnesium intake shows promise as a predictor of the condition. However, the relationship between low dietary magnesium intake and an increased risk of PAD remains uncertain, and further research is needed to clarify this relationship.
This study analyzed data from 5969 participants in the National Health and Nutrition Examination Survey (NHANES) of the United States from 1999 to 2004. Multifactorial logistic regression models were used to investigate the association between dietary magnesium intake and PAD.
Participants with PAD had lower dietary magnesium intake compared to those without PAD. After adjusting for all covariates, dietary magnesium intake remained negatively associated with PAD (OR: 0.999, 95% CI: 0.998, 1.000). When dietary magnesium intake was divided into quartiles, compared with the fourth quantile, the first quartile is associated with a higher incidence rate of PAD (OR: 1.560, 95%CI: 1.019, 2.386). Subgroup analysis revealed that the link between dietary magnesium intake and PAD remained significant among specific subgroups, including non-white, never or former smokers, and non-hypertensive, non-diabetic individuals (P < 0.05).
Our study provides evidence that dietary magnesium intake is negatively associated with the incidence of PAD. Therefore, people with inadequate dietary magnesium intake, particularly those with excessively low intake, should increase their magnesium intake to reduce the risk of PAD.
已发现镁与外周动脉疾病（PAD）密切相关，膳食镁摄入量有望成为该疾病的一个预测指标。然而，膳食镁摄入量低与PAD风险增加之间的关系仍不明确，需要进一步研究来阐明这种关系。
本研究分析了1999年至2004年美国国家健康与营养检查调查（NHANES）中5969名参与者的数据。采用多因素逻辑回归模型研究膳食镁摄入量与PAD之间的关联。
与无PAD的参与者相比，患有PAD的参与者膳食镁摄入量较低。在对所有协变量进行调整后，膳食镁摄入量仍与PAD呈负相关（比值比：0.999，95%置信区间：0.998，1.000）。当将膳食镁摄入量分为四分位数时，与第四分位数相比，第一分位数与PAD的发病率较高相关（比值比：1.560，95%置信区间：1.019，2.386）。亚组分析显示，在特定亚组中，包括非白人、从不吸烟或曾经吸烟的人以及非高血压、非糖尿病个体，膳食镁摄入量与PAD之间的联系仍然显著（P<0.05）。
我们的研究提供了证据表明膳食镁摄入量与PAD的发病率呈负相关。因此，膳食镁摄入量不足的人，特别是摄入量过低的人，应增加镁的摄入量以降低患PAD的风险。
